VCRC LONGITUDINAL STUDY FOR WEGENER'S GRANULOMATOSIS AND MICROSCOPIC POLYANGITIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项纵向的观察性队列研究。这项研究的主要目的是开发新的血管炎生物标志物，用于诊断、疾病活动性测量、疾病损害评估、疾病状态确定和治疗反应评估。将有300个科目在4个中心招收。 韦格纳肉芽肿病(WG)和显微镜下的多血管炎(MPA)是血管炎的一种形式，影响到中小型血管。WG/MPA对男性和女性的影响频率相同，也可发生在儿童中。这项研究中确定和开发的实验性生物标记物测试系统将有助于确定WG/MPA患者的疾病鉴别诊断、疾病活动性和治疗反应的测量以及临床结果的预测。这项研究将在美国的四个主要脉管炎中心进行，利用每个地点的GCRC。在五年的随访期内，将收集所有患者的一套全面的临床和实验室数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a longitudinal, observational cohort study. The primary objective of this study is to develop new biomarkers for vasculitis for purposes of diagnosis, disease activity measurement, disease damage assessment, determination of disease state and evaluation of treatment response. There will be 300 subjects enrolled over 4 centers. Wegener's granulomatosis (WG) and Microscopic polyangitis (MPA) are forms of vasculitis, affecting the medium and small vessels. WG/MPA affects both men and women with equal frequency and can also occur in children. The experimental biomarker testing systems identified and developed in this study will assist in determining diagnostic disease differentiation, measures of disease activity and response to treatment, and prediction of clinical outcomes for patients with WG/MPA. The study will be conducted at four major vasculitis centers in the US, utilizing the GCRC at each site. A comprehensive set of clinical and laboratory data will be collected on all patients during a five year follow-up period.