VCRC LONGITUDINAL STUDY FOR WEGENER'S GRANULOMATOSIS AND MICROSCOPIC POLYANGITIS

韦格纳肉芽肿病和显微多血管炎的 VCRC 纵向研究

• 批准号: 7606276
• 负责人: Peter A Merkel
• 金额: $ 1.74万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606276
• 关键词: Affect; Biological Markers; Child; Clinical; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Data; Diagnosis; Diagnostic; Disease; Enrollment; Evaluation; Frequencies; Funding; Grant; Institution; Laboratories; Longitudinal Studies; Measurement; Measures; Microscopic; Outcome; Patients; Purpose; Research; Research Personnel; Resources; Site; Source; System; Testing; United States National Institutes of Health; Vasculitis; Wegener' s Granulomatosis; Woman; follow-up; men; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a longitudinal, observational cohort study. The primary objective of this study is to develop new biomarkers for vasculitis for purposes of diagnosis, disease activity measurement, disease damage assessment, determination of disease state and evaluation of treatment response. There will be 300 subjects enrolled over 4 centers. Wegener's granulomatosis (WG) and Microscopic polyangitis (MPA) are forms of vasculitis, affecting the medium and small vessels. WG/MPA affects both men and women with equal frequency and can also occur in children. The experimental biomarker testing systems identified and developed in this study will assist in determining diagnostic disease differentiation, measures of disease activity and response to treatment, and prediction of clinical outcomes for patients with WG/MPA. The study will be conducted at four major vasculitis centers in the US, utilizing the GCRC at each site. A comprehensive set of clinical and laboratory data will be collected on all patients during a five year follow-up period.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项纵向、观察性队列研究。本研究的主要目的是开发新的血管炎生物标志物，用于诊断、疾病活动性测量、疾病损害评估、确定疾病状态和评价治疗反应。将有300例受试者在4家临床试验机构入组。 韦格纳肉芽肿病（WG）和显微镜下多血管炎（MPA）是血管炎的形式，影响中，小血管。WG/MPA以相同的频率影响男性和女性，也可发生在儿童中。本研究中确定和开发的实验生物标志物检测系统将有助于确定诊断疾病的分化，疾病活动和治疗反应的措施，以及WG/MPA患者的临床结局预测。本研究将在美国的四家主要血管炎中心进行，每家中心均使用GCRC。将在5年随访期内收集所有患者的一组全面的临床和实验室数据。