VCRC LONGITUDINAL STUDY FOR TAKAYASU'S ARTERITIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 研究设计：这是一项纵向观察性队列研究。 研究目的：本研究的主要目的是开发新的血管炎生物标志物，用于诊断、疾病活动性测量、疾病损害评估、疾病状态确定和治疗反应评价。 研究药物：不适用 受试者数量：160 中心数量：4 大动脉炎是一种血管炎，影响大动脉（主动脉及其分支）。多发性大动脉炎影响女性的频率高于男性，通常在成年早期开始，但也可发生在儿童中。本研究中确定和开发的实验生物标志物检测系统将有助于确定诊断疾病的分化，疾病活动和治疗反应的措施，以及预测患有大动脉炎的患者的临床结果。本研究将在美国的四家主要血管炎中心进行，每家中心均使用GCRC。将在5年随访期内收集所有患者的一组全面的临床和实验室数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Study Design: This is a longitudinal, observational cohort study. Study Objectives: The primary objective of this study is to develop new biomarkers for vasculitis for purposes of diagnosis, disease activity measurement, disease damage assessment, determination of disease state and evaluation of treatment repsonse. Study Medication: N/A Number of Subjects: 160 Number of Centers: 4 Takayasu's arteritis is a form of vasculitis, affecting large arterities (aorta and its branches). Takayasu's arteritis affects women with greater frequency than men and usually begins in arly adulthood but can also occur in children. The experimental biomarker testing systems identified and developed in this study will assist in determining diagnostic disease differentiation, measures of disease activity and response to treatment, and prediction of clinical outcomes for aptients with Takayasu's arteritis. The study will be conducted at four major vasculitis centers in the US, utilizing the GCRC at each site. A comprehensive set of clinical and laboratory data will be collected on all patients during a five year follow-up period.