VITAMIN D SUPPLEMENTATION AND BONE CHANGES IN SICKLE CELL DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 镰状细胞病是由于β珠蛋白基因的密码子6中腺嘌呤（A）被胸腺嘧啶（T）取代，这指定了缬氨酸取代谷氨酸的插入。这种疾病发生在1：900的风险个体（非洲裔美国人，西班牙裔）。它导致脱氧时血红蛋白分子聚合，从而导致终末器官损伤，表现为骨缺血性坏死、中风和弥漫性骨质减少。维生素D缺乏症在非裔美国人中相对常见，估计老年人的患病率为21%。对维生素D不足的解释可能是多因素的-营养摄入不足，缺乏阳光照射和皮肤色素沉着增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sickle cell disease results from an Adenine(A) to Thymine (T) substitution in codon 6 of the beta globin gene which specifies the insertion of valine in place of glutamic acid. This disease occurs in 1:900 at risk individuals (African Americans, Hispanics). It results in polymerization of the hemoglobin molecule upon deoxygenation, which leads to end-organ damage manifest as avascular necrosis of bone, stroke and diffuse osteopenia. Vitamin D deficiency is relatively common in African Americans with an estimated prevalence of 21% in the elderly. The explanations for vitamin D insufficiency are likely multifactor - poor nutritional intake, lack of sun exposure and increased skin pigmentation.