VITAMIN D SUPPLEMENTATION AND BONE CHANGES IN SICKLE CELL DISEASE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。镰状细胞病是由β珠蛋白基因第6密码子中腺嘌呤(A)到胸腺嘧啶(T)的替换引起的，该密码子规定了插入缬氨酸而不是谷氨酸。这种疾病发生在1：900的高危人群中(非裔美国人、西班牙裔美国人)。它导致血红蛋白分子在脱氧时聚合，导致终末器官损害，表现为骨缺血性坏死、中风和弥漫性骨量减少。维生素D缺乏症在非裔美国人中相对常见，据估计，老年人的患病率为21%。维生素D不足的原因可能是多方面的--营养摄入不足，缺乏阳光照射，以及皮肤色素沉着增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sickle cell disease results from an Adenine(A) to Thymine (T) substitution in codon 6 of the beta globin gene which specifies the insertion of valine in place of glutamic acid. This disease occurs in 1:900 at risk individuals (African Americans, Hispanics). It results in polymerization of the hemoglobin molecule upon deoxygenation, which leads to end-organ damage manifest as avascular necrosis of bone, stroke and diffuse osteopenia. Vitamin D deficiency is relatively common in African Americans with an estimated prevalence of 21% in the elderly. The explanations for vitamin D insufficiency are likely multifactor - poor nutritional intake, lack of sun exposure and increased skin pigmentation.