VENTRAL STRIATAL DOPAMINE RESPONSE TO ETHANOL AND ITS CUES IN AT-RISK DRINKERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 动物模型显示，多巴胺(DA)区域，如腹侧被盖区(VTA)和伏隔核(NAC)是大脑奖赏回路的关键部分，并与酒精中毒的遗传学有关。我们建议使用正电子发射断层扫描(PET)来研究[11C[raclopide(Rac，D2/D3配体)]的结合电位变化(BP)作为酒精预期和饮酒的函数，这些受试者是酒精中毒的风险受试者-有酒精中毒家族史的高酒精饮酒者(HED)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Animal models show that dopamine (DA) regions such as the ventral tegmental area (VTA) and nucleus accumbens (NAc) are critical parts of the brain's reward circuit, and are implicated in the genetics of alcoholism. We propose using positron emission tomography (PET) to study binding potential changes (BP) in [11C[ Raclopride (RAC, D2/D3 ligand) as a function of ethanol anticipation and consumption in subjects at risk for alcoholism -- High-ethanol drinkers (HED) with a family history of alcoholism (FHA).