PROTEOMIC ANALYSIS OF CEREBROSPINAL FLUID (CSF) IN PATIENTS WITH HEREDITARY ATAX

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 来自遗传性神经退行性疾病患者的脊髓液，包括脊髓小脑性共济失调、亨廷顿病和其他家族性共济失调，将通过一种名为“表面增强激光解吸/电离飞行时间光谱仪”的蛋白质芯片阵列技术进行分析。从这项分析中获得的信息将与健康对照受试者的脑脊液进行比较，以确定是否存在与共济失调亚型或疾病阶段相关的模式。如果存在相关性，就可以开发“光谱指纹”作为诊断工具。以前的初步研究显示了显著不同的蛋白质组模式，这可能有助于诊断和疾病状态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The spinal fluid from patients with hereditary neurodegenerative diseases including spinocerebellar ataxia, Huntington's disease, and other familial ataxias will be analyzed by a protein chip array technology called "surface enhanced laser desorption/ionization-time of flight spectrometery". The information obtained from this analysis will be compared to CSF from healthy control subjects to determine if a pattern exists which correlates with the subtype of ataxia or stage of disease. If a correlation exists, a "spectrometric fingerprint" could be developed as a diagnostic tool. Previous pilot studies revealed significantly different proteomic patterns which could be useful for diagnosis and disease state.