PROTEOMIC ANALYSIS OF CEREBROSPINAL FLUID (CSF) IN PATIENTS WITH HEREDITARY ATAX

遗传性共济失调患者脑脊液 (CSF) 的蛋白质组学分析

• 批准号: 7606059
• 负责人: Khalaf O Bushara
• 金额: $ 0.6万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606059
• 关键词: Ataxia; Cerebrospinal Fluid; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Diagnostic; Disease; Fingerprint; Funding; Grant; Huntington Disease; Inherited; Institution; Nervous System Heredodegenerative Disorders; Patients; Pattern; Pilot Projects; Protein Microchips; Proteomics; Research; Research Personnel; Resources; Source; Spinocerebellar Ataxias; Staging; Technology; Time; United States National Institutes of Health; surface enhanced laser desorption ionization; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The spinal fluid from patients with hereditary neurodegenerative diseases including spinocerebellar ataxia, Huntington's disease, and other familial ataxias will be analyzed by a protein chip array technology called "surface enhanced laser desorption/ionization-time of flight spectrometery". The information obtained from this analysis will be compared to CSF from healthy control subjects to determine if a pattern exists which correlates with the subtype of ataxia or stage of disease. If a correlation exists, a "spectrometric fingerprint" could be developed as a diagnostic tool. Previous pilot studies revealed significantly different proteomic patterns which could be useful for diagnosis and disease state.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 来自患有遗传性神经退行性疾病（包括脊髓小脑共济失调、亨廷顿病和其他家族性共济失调）的患者的脊髓液将通过一种名为“表面增强激光解吸/电离飞行时间光谱法”的蛋白质芯片阵列技术进行分析。从该分析中获得的信息将与来自健康对照受试者的脑脊液进行比较，以确定是否存在与共济失调亚型或疾病阶段相关的模式。如果存在相关性，则可以开发“光谱指纹”作为诊断工具。先前的试点研究揭示了显着不同的蛋白质组模式，这可能有助于诊断和疾病状态。