NEUROANATOMICAL AND BIOCHEMICAL CORRELATES OF LOW BACK PAIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项可行性研究，评估神经和炎症介质如阿片类药物、生长因子和细胞因子在正常受试者和诊断为严重退行性腰椎间盘疾病(DDD)的下腰痛(LBP)患者中的表达。10名实验受试者(LBP患者)将从预定手术治疗DDD引起的慢性LBP的患者中招募。除了对所有受试者进行全面、标准化的身体和功能评估外，我们还将回顾每个病例的病史，包括腰椎区域的磁共振成像(MRI)。将对数据进行评估，以确定每个标志物与由于DDD引起的LBP的物理功能影响之间的相关性。这些数据将使我们能够确定这种实验方法的健壮性；更大规模、更全面的研究的可行性；以及如何最好地设计未来的研究，以确保足够的动力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a feasibility study evaluating the expression of neurological and inflammatory mediators such as opioids, growth factors and cytokines in normal subjects versus low back pain (LBP) patients diagnosed with severe degenerative disk disease (DDD). Ten experimental subjects (LBP patients) will be recruited from a population of patients scheduled for surgery to treat chronic LBP due to DDD. In addition to a comprehensive, standardized physical and functional assessment of all subjects, we will perform a review of each case history, including magnetic resonance imaging (MRI) of the lumbar region. The data will be evaluated for correlations between each marker and the physical functional impact of LBP due to DDD. These data will allow us to determine how robust this experimental approach is; how feasible a larger more comprehensive study would be; and how to best design future studies to ensure adequate power.