NEUROANATOMICAL AND BIOCHEMICAL CORRELATES OF LOW BACK PAIN

腰痛的神经解剖学和生物化学相关性

• 批准号: 7606025
• 负责人: LAURA S STONE
• 金额: $ 0.19万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606025
• 关键词: Biochemical; Chronic low back pain; Computer Retrieval of Information on Scientific Projects Database; Data; Diagnosis; Disease; Ensure; Feasibility Studies; Funding; Future; Grant; Growth Factor; Inflammatory; Institution; Low Back Pain; Lumbar Regions; Magnetic Resonance Imaging; Mediator of activation protein; Neurologic; Operative Surgical Procedures; Opioid; Patient Schedules; Patients; Population; Recruitment Activity; Research; Research Personnel; Resources; Source; United States National Institutes of Health; case history; cytokine; design

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a feasibility study evaluating the expression of neurological and inflammatory mediators such as opioids, growth factors and cytokines in normal subjects versus low back pain (LBP) patients diagnosed with severe degenerative disk disease (DDD). Ten experimental subjects (LBP patients) will be recruited from a population of patients scheduled for surgery to treat chronic LBP due to DDD. In addition to a comprehensive, standardized physical and functional assessment of all subjects, we will perform a review of each case history, including magnetic resonance imaging (MRI) of the lumbar region. The data will be evaluated for correlations between each marker and the physical functional impact of LBP due to DDD. These data will allow us to determine how robust this experimental approach is; how feasible a larger more comprehensive study would be; and how to best design future studies to ensure adequate power.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项评价正常受试者与诊断为重度退行性椎间盘疾病（DDD）的腰痛（LBP）患者中神经和炎症介质（如阿片类药物、生长因子和细胞因子）表达的可行性研究。将从计划手术治疗DDD所致慢性LBP的患者人群中招募10名实验受试者（LBP患者）。除了对所有受试者进行全面、标准化的身体和功能评估外，我们还将对每个病例的病史进行审查，包括腰椎区域的磁共振成像（MRI）。将对数据进行评价，以确定每种标志物与DDD导致的LBP身体功能影响之间的相关性。这些数据将使我们能够确定这种实验方法的稳健性;更大规模更全面的研究的可行性;以及如何最好地设计未来的研究以确保足够的功效。