INSULIN SENSITIVITY AND VASCULAR FUNCTION IN NON-ALCOHOLIC STEATOHEPATITIS-NASH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 NASH是无病毒性肝炎和酒精相关疾病的受试者中肝硬化的最常见原因。 在肥胖受试者中经常观察到NASH，表明胰岛素抵抗的潜在作用。 NASH的原因尚不清楚，但可能是由于血管和/或代谢变化或两者的组合。 为了更好地理解血管功能和葡萄糖代谢之间的关系，我们计划评估患有活检证实的NASH的受试者对内皮依赖性和非依赖性血管扩张剂的腿部血流反应和胰岛素敏感性。 将通过热稀释技术评价腿部血流量。 将使用正常血糖高胰岛素钳夹测量胰岛素敏感性。 我们将比较我们的研究结果与我们自己的规范性数据（与肥胖相匹配的女性研究）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NASH is the most common cause of liver cirrhosis in subjects without viral hepatitis and alcohol related disease. NASH is frequently observed in obese subjects suggesting a potential role of insulin resistance. The cause of NASH is not known but may be due to vascular and/or metabolic changes or a combination of each. To gain better understanding of the relation between vascular function and glucose metabolism we plan to assess leg blood flow responses to endothelium-dependent and -independent vasodilators and insulin sensitivity in subjects with biopsy proven NASH. Leg blood flow will be evaluated by thermodilution technique. Insulin sensitivity will be measured using the euglycemic hyperinsulinemic clamp. We will compare results of our study with out own normative data (studies with females matched for obesity).