INSULIN SENSITIVITY AND VASCULAR FUNCTION IN NON-ALCOHOLIC STEATOHEPATITIS-NASH

非酒精性脂肪性肝炎-NASH 的胰岛素敏感性和血管功能

• 批准号: 7606392
• 负责人: HELMUT O STEINBERG
• 金额: $ 0.1万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606392
• 关键词: Alcohols; Biopsy; Blood Vessels; Blood flow; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Endothelium; Female; Funding; Grant; Institution; Insulin Resistance; Leg; Liver Cirrhosis; Measures; Metabolic; Obesity; Research; Research Personnel; Resources; Role; Source; Techniques; Thermodilution; United States National Institutes of Health; Vasodilator Agents; Viral hepatitis; glucose metabolism; insulin sensitivity; nonalcoholic steatohepatitis; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NASH is the most common cause of liver cirrhosis in subjects without viral hepatitis and alcohol related disease. NASH is frequently observed in obese subjects suggesting a potential role of insulin resistance. The cause of NASH is not known but may be due to vascular and/or metabolic changes or a combination of each. To gain better understanding of the relation between vascular function and glucose metabolism we plan to assess leg blood flow responses to endothelium-dependent and -independent vasodilators and insulin sensitivity in subjects with biopsy proven NASH. Leg blood flow will be evaluated by thermodilution technique. Insulin sensitivity will be measured using the euglycemic hyperinsulinemic clamp. We will compare results of our study with out own normative data (studies with females matched for obesity).

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