CONTEMPORARY SCREENING FOR THE DETECTION OF LUNG CANCER

肺癌检测的当代筛查

• 批准号: 7606918
• 负责人: PHILLIP M BOISELLE
• 金额: $ 3.17万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606918
• 关键词: Blood; Chest; Computer Retrieval of Information on Scientific Projects Database; Detection; Dose; End Point; Enrollment; Event; Funding; Genetic; Grant; Image; Individual; Institution; Malignant Neoplasms; Malignant neoplasm of lung; Randomized; Randomized Controlled Clinical Trials; Relative (related person); Research; Research Personnel; Resources; Risk; Screening procedure; Source; Spiral Computed Tomography; Sputum; Thoracic Radiography; Tissue Banks; United States National Institutes of Health; Upper arm; Urine; cohort; low-dose spiral CT; lung cancer screening; mortality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary aim of this randomized trial is to determine whether lung cancer screening using low-dose helical CT reduces lung cancer-specific mortality relative to screening with chest radiographs in a high risk cohort. A secondary aim is to develop a tissue bank from individuals at high risk of lung cancer both with and without pathologically proven lung cancers. 1000 subjects will be enrolled in the trial at BIDMC over a 3 year period; half will be randomized to low dose spiral CT (experimental arm) and half will be randomized to chest radiography (control arm). The primary endpoint of the imaging part of the study is lung cancer specific mortality. In the bio-marker portion of the study, the hypothesis is that biomolecular markers may be identified in blood, sputum or urine which can enhance understanding of genetic events preceding and associated with cancer.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项随机试验的主要目的是确定与高危队列中的胸部X线片筛查相比，使用低剂量螺旋CT进行肺癌筛查是否可以降低肺癌特异性死亡率。第二个目标是建立一个来自肺癌高危人群的组织库，这些人既有肺癌的高危人群，也有经病理证实的肺癌患者。1000名受试者将在BIDMC参加为期3年的试验；一半将随机接受低剂量螺旋CT(实验组)，一半将随机接受胸部X光检查(对照组)。这项研究的成像部分的主要终点是肺癌特异性死亡率。在这项研究的生物标记部分，假设可能在血液、痰或尿液中发现生物分子标记，这些标记可以增强对癌症之前和与癌症相关的遗传事件的了解。