ISLET TRANSPLANTATION IN TYPE I DIABETIC REICIPIENTS OF RENAL ALLOGRAFT USING TH

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In Type 1 diabetes, islet cells in the pancreas, which make insulin, are thought to be destroyed in an immune response. Islet cell transplantation is a procedure that is being tested as an experimental therapy in individuals with difficult to control Type 1 diabetes who are already on immunosuppression following a kidney transplant. In this protocol, islet cells are harvested from a donor and cultured for infusion. This is an open label, feasibility study whose primary purpose is to test whether islet transplantation results seen in Edmonton, Canada can be repeated in immunosuppressed kidney transplant patients and to test the safety of this investigational procedure. The study will consist of a screening evaluation, the treatment phase, and a follow-up phase lasting approximately 12 months.