利妥昔单抗在具有早期抗 HLA 同种抗体的同种异体肾移植受者中的应用-猫眼课题宝

利妥昔单抗在具有早期抗 HLA 同种抗体的同种异体肾移植受者中的应用

批准号：

7606964

负责人：

MARTHA PAVLAKIS

金额：

$0.53万

依托单位：

BETH ISRAEL DEACONESS MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

2007

资助国家：

美国

项目状态：

已结题

起止时间：

2007-04-01 至 2008-03-31

来源：

https://reporter.nih.gov/project-details/7606964

关键词：

B-Lymphocytes Chronic Computer Retrieval of Information on Scientific Projects Database Effectiveness End Point Functional disorder Funding Grant Institution Isoantibodies Randomized Research Research Personnel Resources Source United States National Institutes of Health kidney allograft randomized placebo controlled trial rituximab

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英文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a multi-center, single-blinded, randomized, placebo-controlled trial. Centers will screen 1200-1400 subjects and will randomize a total of 134 subjects over 3 years. The primary endpoint of this study is the effectiveness of B-cell depletion by anti-CD20 mAb therapy in reducing progression of chronic renal allograft dysfunction by chronic humoral rejection.

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