HEMODIALYSIS-INDUCED HYPERGLYCEMIA AND ITS EFFECTS ON INFLAMMATORY CYTOKINES

血液透析引起的高血糖及其对炎症细胞因子的影响

• 批准号: 7606721
• 负责人: MITCHELL H ROSNER
• 金额: $ 0.09万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606721
• 关键词: Anti-Inflammatory Agents; Anti-inflammatory; Biological Markers; C-reactive protein; Computer Retrieval of Information on Scientific Projects Database; Dialysis procedure; Elevation; End stage renal failure; Etiology; Event; Experimental Models; Funding; Glucose; Grant; Hemodialysates; Hemodialysis; High Density Lipoproteins; Hour; Hyperglycemia; Hypertension; Inflammation; Inflammatory; Institution; Interleukin-10; Interleukin-6; Lead; Measures; Morbidity - disease rate; Patients; Personal Satisfaction; Physical Dialysis; Physiological; Production; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Solutions; Source; United States National Institutes of Health; cardiovascular risk factor; cytokine; mortality; non-diabetic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with end-stage renal disease (ESRD) are at extremely high risk for cardiovascular (CV) morbidity and mortality. While some of the increased risk of CV events can be explained by traditional risk factors (such as hypertension, low HDL levels), much of the increased risk is likely associated with non-traditional risk factors. Perhaps, foremost among these is the presence of an active underlying inflammatory state as measured by elevated levels of inflammatory biomarkers such as C-reactive protein and cytokines. The etiology of this pro-inflammatory state has not been well delineated and likely derives from both features associated with the uremic state as well as features due to the dialysis procedure itself. This study aims to investigate the role of the hemodialysate solution in leading to active inflammation in ESRD patients. Non-diabetic hemodialysis patients are exposed to non-physiological levels of glucose (200 mg/dL) during each dialysis session for 3-4 hours. Experimental models have demonstrated that hyperglycemia can stimulate the production of pro-inflammatory cytokines. The aim of this study is to determine if modulating the dialysate glucose concentration can lead to reductions in pro-inflammatory cytokines (IL-6, C-reactive protein, IL-1¿ and TNF-a) and elevations in anti-inflammatory cytokines (IL-10).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 终末期肾病（ESRD）患者的心血管（CV）发病率和死亡率风险极高。 虽然一些CV事件风险增加可以通过传统风险因素（如高血压、低HDL水平）解释，但大部分风险增加可能与非传统风险因素相关。 也许，其中最重要的是存在活性潜在炎症状态，如通过升高的炎症生物标志物（如C反应蛋白和细胞因子）水平所测量的。 这种促炎状态的病因尚未得到很好的描述，可能来自与尿毒症状态相关的特征以及透析程序本身的特征。 本研究旨在研究血液透析液在导致ESRD患者活动性炎症中的作用。 非糖尿病血液透析患者在每次透析期间暴露于非生理水平的葡萄糖（200 mg/dL）3-4小时。 实验模型已经证明，高血糖症可以刺激促炎细胞因子的产生。 本研究的目的是确定调节透析液葡萄糖浓度是否会导致促炎细胞因子（IL-6、C-反应蛋白、IL-1？和TNF-α）减少和抗炎细胞因子（IL-10）升高。