A RANDOMIZED STUDY OF INJECTION-HEMOCLIPPING COMPARED TO INJECTION-MULTIPOLAR

注射夹钳与注射多极的随机研究

• 批准号: 7606821
• 负责人: DENNIS MICHAEL JENSEN
• 金额: $ 0.07万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-21 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606821
• 关键词: Acute; Aftercare; Archives; Blood Platelets; Caliber; Case Study; Colon; Colonoscopy; Combined Modality Therapy; Complication; Computer Retrieval of Information on Scientific Projects Database; Depth; Direct Costs; Distal; Educational process of instructing; Endoscopic Hemostasis; Epinephrine; Erythrocytes; Flexible fiberoptic sigmoidoscopy; Fresh Frozen Plasmas; Funding; Genus Cola; Grant; Hemorrhage; Hemostatic function; Hospitals; Injection of therapeutic agent; Institution; Intensive Care Units; Lesion; Non-Malignant; Operative Surgical Procedures; Outcome; Patients; Publications; Purpose; Randomized; Rate; Research; Research Personnel; Resources; Retreatment; Safety; Source; Transfusion; Treatment Failure; United States National Institutes of Health; Week; day; digital imaging; mortality; size

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS 1. To compare the efficacy and safety of two endoscopic combination therapies (epinephrine injection plus either multipolar probe or hemoclipping) for hemostasis of non-variceal, non-malignant, or non-angiomatous colonic hemorrhage. 2. To compare the proportion of lesions with a significant decrease in size from baseline at 3 weeks colonoscopy or flexible sigmoidoscopy (if in distal colon). 3. To quantitate and compare endoscopic lesion sizes (diameter and depth) before vs. immediately after endoscopic treatments; and before endoscopic treatment vs. 3 weeks on colonoscopy (or flexible sigmoidoscopy). 4. To quantitate and compare routine outcomes after endoscopic hemostasis with the two different treatments, including primary and permanent hemostasis rates; rates of treatment failure and crossover to the other treatment (for failure of acute hemostasis, severe rebleeding necessitating retreatment, or a severe treatment complication); transfusions (units red blood cells, platelets, and fresh frozen plasma- total and post-randomization); duration of hospital and intensive care unit stay; complications; surgery; and mortality rates at 7 and 30 days after randomization. 5. To estimate and compare direct costs of care, after randomization of patients. 6. To record, edit, and archive digital images and videoclips of study cases for publication and teaching purposes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 具体目标 1。为了比较两种内窥镜组合疗法（肾上腺素注射以及多极探针或血胶的疗效）对于非交易，非恶性或非血管瘤性结肠出血的止血。 2。要比较3周结肠镜检查的基线或柔性乙状结肠镜检查的病变比例显着降低（如果在远端结肠中）。 3。定量和比较内窥镜治疗前与立即在内窥镜治疗之前的内窥镜病变大小（直径和深度）；在内窥镜治疗与结肠镜检查（或柔性乙状结肠镜检查）的3周之前。 4。定量和比较内窥镜止血后的常规结局与两种不同的治疗方法，包括原发性和永久性止血率；治疗率失败和其他治疗的交叉（对于急性止血，严重再出血需要恢复或严重的治疗并发症）；输血（单位红细胞，血小板和新鲜的冷冻血浆总和随机后）；医院和重症监护病房的持续时间；并发症；外科手术;随机分组后7和30天的死亡率。 5。估计并比较患者随机分组后的直接护理费用。 6。记录，编辑和存档数字图像和研究案例的录像带，以出版和教学目的。