BLOOD PRESSURE CONTROL

血压控制

• 批准号: 7606514
• 负责人: MICHAEL G. ZIEGLER
• 金额: $ 1.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606514
• 关键词: Adrenergic Receptor; Adrenergic beta-Agonists; Agonist; Computer Retrieval of Information on Scientific Projects Database; Environmental air flow; Essential Hypertension; Funding; Genetic Polymorphism; Grant; Hypotension; Institution; Nitrates; Nitric Oxide; Orthostatic Hypotension; Patients; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Variant; Vasodilation; Venous; beta-2 Adrenergic Receptors; blood pressure regulation; nitrate; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with essential hypertension who have impaired arterial vasodilation in response to endogenous nitric oxide and beta adrenergic agonists will have normal ventilation in response to nitrates and beta agonists. Patients with essential hypertension have exaggerated pressor responses to alpha agonists will have normal venoconstrictor responses to alpha agonists. Patients with low blood pressure and postural hypotension will have exaggerated arterial and venous dilation in response to nitric oxide. Polymorphisms of the beta-2-adrenergic receptor and alpha-1 adrenergic receptors will explain some but not all of the variations in pharmacological responses to these agents.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 对内源性一氧化氮和β肾上腺素能激动剂的反应导致动脉血管舒张受损的原发性高血压患者，对硝酸盐和β受体激动剂的反应将具有正常的通气能力。原发性高血压患者对α激动剂有过度的升压反应，但对α激动剂有正常的静脉收缩反应。低血压和体位性低血压患者会因一氧化氮而出现过度的动脉和静脉扩张。 β-2-肾上腺素能受体和α-1肾上腺素能受体的多态性将解释对这些药物的药理反应的一些但不是全部变化。