DENDRITIC CELLS (DC) CROSSTALK

树突状细胞 (DC) 串扰

• 批准号: 7607589
• 负责人: BIJAY MUKHERJI
• 金额: $ 0.17万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607589
• 关键词: Acids; Computer Retrieval of Information on Scientific Projects Database; Cytotoxic T-Lymphocytes; Dendritic Cells; Funding; Generations; Goals; Grant; Human; Institution; Regulation; Research; Research Personnel; Resources; Source; Testing; Thioacetamide; United States National Institutes of Health; Vaccine Design; base; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of this proposal is to test the hypothesis that Crosstalk in Cytotoxic T Lymphocytes (CTL) response against human thioacetamide acid (TAA) induced by Dendritic Cells (DC)-based stimulation is subject to regulation by DC-Th cross-talks. A better understanding of the rules of the engagement of DC-Th cross-talks that govern the generation and the control of anti-TAA CTL response will have a major impact in DC-based vaccine design.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本提案的主要目标是检验以下假设：基于树突状细胞（DC）的刺激诱导的细胞毒性T淋巴细胞（CTL）对人硫代乙酰胺酸（TAA）的应答中的串扰受到DC-Th串扰的调节。 更好地了解DC-Th交叉谈判的参与规则，这些规则控制抗TAA CTL应答的产生和控制，将对基于DC的疫苗设计产生重大影响。