DENDRITIC CELLS (DC) CROSSTALK

树突状细胞 (DC) 串扰

• 批准号: 7377317
• 负责人: BIJAY MUKHERJI
• 金额: $ 0.46万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377317
• 关键词: DENDRITIC; CELLS; DC; CROSSTALK

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of this proposal is to test the hypothesis that CTL response against human TAA induced by DC-based stimulation is subject to regulation by DC-Th cross-talks. A better understanding of the rules of the engagemnet of DC-Th cross-talks that govern the generation and the control of anti-TAA CTL response will have a major impact in DC-based vaccine design.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。该提案的主要目标是检验以下假设：基于 DC 的刺激诱导的针对人类 TAA 的 CTL 反应受到 DC-Th 串扰的调节。更好地理解控制抗 TAA CTL 反应的产生和控制的 DC-Th 串扰网络的规则将对基于 DC 的疫苗设计产生重大影响。