ATOM

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 待检验的具体假设是：1）对患有大麻使用障碍的青少年实施基于维生素B1的强化疗法（VBRT）是可行的，对青少年和治疗师都是可以接受的; 2）青少年VBRT在治疗期间和治疗完成时减少了大麻的使用; 3）青少年VBRT强化相对于非强化对照条件增强了大麻使用的上级减少。拟议的试验遵循由国家药物滥用研究所（NIDA）开发的初步I期研究的指南（Rounsaville等人，2001年）。 第一阶段项目的目标是：1）确定第二阶段项目是否适用于第一阶段项目中检查的治疗; 2）如果适用，则提供支持第二阶段应用所需的必要程序、手册、措施和数据（例如，效应量估计）。II期项目的适当性决定意味着生成的数据支持针对该疾病和/或其旨在治疗的行为检查的治疗的可行性和临床效用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific hypotheses to be tested are 1) Implementation of Voucher Based Reinforcement Therapy (VBRT) for youth with Cannabis Use Disorder is feasible and acceptable for both youths and therapists; 2) VBRT for youth produces a reduction of cannabis use during and at the completion of treatment; and 3) VBRT reinforcement for youth enhances a superior reduction of cannabis use relative to the non-reinforcement control condition. The proposed trial follows the guidelines for a preliminary Stage I study developed by the National Institute of Drug Abuse (NIDA) (Rounsaville et al., 2001). The goals of a Stage I project are 1) to determine whether or not a Stage II project is indicated for the therapy examined in a Stage I project, and 2) if so, provide the necessary procedures, manuals, measures, and data needed to support a Stage II application (e.g., effect size estimates). Decision on appropriateness of Stage II project implies that the data generated supports the feasibility and clinical utility of the therapy examined for that condition, and/or behavior that it is designed to treat.