ZONISAMIDE VERSUS PLACEBO

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a pilot study designed to examine the potential efficacy and tolerability of zonisamide for the treatment of alcoholism, and to compare this to topiramate, a similar medicine with demonstrated efficacy in a randomized clinical trial. Zonisamide is potentially better tolerated and easier to titrate in the outpatient setting than topiramate.