H/H-ASTHMA (HGC)

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 尽管我们对哮喘的病理生理学的理解有了显著的进步，治疗哮喘的疗法也有了显著的改进，但弱势群体和少数群体仍然承受着不成比例的哮喘负担。 这种现象的确切原因尚不清楚，然而，已经提出了一些因素来解释这种差异，包括哮喘易感性或哮喘严重程度的遗传差异，环境暴露的差异率，（如蟑螂、灰尘）不同社会经济状况的患者在哮喘医疗护理的可及性和质量方面的差异以及哮喘自我管理实践不足，包括治疗依从性差 人们普遍认为，这些因素相互作用，导致低收入，非洲裔美国儿童和成人哮喘患者中观察到的哮喘负担过重。 本申请借鉴了这一丰富的历史，提出这些机构和研究人员的正式合作，作为霍华德/霍普金斯减少哮喘差异中心的一部分。 具体来说，本申请提出了四个研究项目，旨在合作调查与城市中心的非洲裔美国儿童和成人所经历的哮喘的治疗负担相关的因素。 该申请包括将评估可能导致非裔美国人社区中观察到的过度风险的潜在遗传因素的研究，以及旨在评估补救该风险的干预策略的研究或提供者-患者沟通。 此外，霍华德/霍普金斯减少哮喘差异中心的一个基本目标是创造一个真正互惠的文化敏感的培训环境，旨在丰富和提高两个参与机构的研究潜力和哮喘管理能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite significant advances in our understanding of the pathphysiology of asthma and marked improvements in the therapies available to treat asthma, disadvantaged and minority communities still carry a disproportionate burden from asthma. The exact reasons for this phenomenon are unknown, however, a number of factors have been proposed to account for this disparity, including genetic differences in vulnerability to asthma or asthma severity, differential rates of environmental exposure (e.g. cockroaches, dust) differences in the accessibility and quality of asthma medical care for patients of differing socioeconomic sttus and inadequate asthma self-management practices, including poor adherence with therapy. It is widely believed that these factors interact to cause the observed excess burden of asthma within low-income, African American children and adults with asthma. This application draws on this rich history to propose the formal collaboration of these institutions and investigators as a part of the Howard/Hopkins Center for Reducing Asthma Disparities. Specifically, this application presents four research projects designed to collaboratively investigate factors associated with the disproportiate burden of asthma experienced by inner-city African-American children and adults. This application includes studies that will evalute both the underlying genetic factors that may contribute to the observed excess risk in African- American communities, as well as studies or provider-patient communication designed to assess intervention strategies for remediating this risk. In addition, an essential goal of the Howard/Hopkins Center for Reducing Asthma Disparities will be to create a culturally sensitive training environment that is truly reciprocal, and designed to both enrich and enhance the research potential and asthma management capabilites of both participating institutions.