H/H-ASTHMA (HGC)

H/H-哮喘 (HGC)

基本信息

  • 批准号:
    7607814
  • 负责人:
  • 金额:
    $ 5.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-03-01 至 2008-02-29
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite significant advances in our understanding of the pathphysiology of asthma and marked improvements in the therapies available to treat asthma, disadvantaged and minority communities still carry a disproportionate burden from asthma. The exact reasons for this phenomenon are unknown, however, a number of factors have been proposed to account for this disparity, including genetic differences in vulnerability to asthma or asthma severity, differential rates of environmental exposure (e.g. cockroaches, dust) differences in the accessibility and quality of asthma medical care for patients of differing socioeconomic sttus and inadequate asthma self-management practices, including poor adherence with therapy. It is widely believed that these factors interact to cause the observed excess burden of asthma within low-income, African American children and adults with asthma. This application draws on this rich history to propose the formal collaboration of these institutions and investigators as a part of the Howard/Hopkins Center for Reducing Asthma Disparities. Specifically, this application presents four research projects designed to collaboratively investigate factors associated with the disproportiate burden of asthma experienced by inner-city African-American children and adults. This application includes studies that will evalute both the underlying genetic factors that may contribute to the observed excess risk in African- American communities, as well as studies or provider-patient communication designed to assess intervention strategies for remediating this risk. In addition, an essential goal of the Howard/Hopkins Center for Reducing Asthma Disparities will be to create a culturally sensitive training environment that is truly reciprocal, and designed to both enrich and enhance the research potential and asthma management capabilites of both participating institutions.
这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金, 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管我们对哮喘的病理生理学的了解取得了重大进展,治疗哮喘的治疗方法也有了显著的改进,但弱势群体和少数群体仍然背负着不成比例的哮喘负担。造成这一现象的确切原因尚不清楚,但已提出若干因素来解释这一差异,包括哮喘易感性或哮喘严重程度的遗传差异、环境暴露(如蟑螂、粉尘)的不同比率、不同社会经济状况患者获得哮喘医疗服务的机会和质量的差异,以及哮喘自我管理做法不足,包括对治疗的依从性不佳。人们普遍认为,这些因素相互作用,导致在低收入、非裔美国儿童和患有哮喘的成年人中观察到哮喘负担过重。这项申请利用这一丰富的历史,建议这些机构和研究人员正式合作,作为霍华德/霍普金斯中心减少哮喘差异的一部分。具体地说,该申请提出了四个研究项目,旨在合作调查与市中心非裔美国儿童和成年人经历的哮喘负担不成比例相关的因素。这项应用包括评估可能导致非裔美国人社区观察到的过度风险的潜在遗传因素的研究,以及旨在评估补救这种风险的干预策略的研究或提供者-患者沟通。此外,霍华德/霍普金斯中心减少哮喘差异的一个重要目标将是创造一个真正互惠的文化敏感的培训环境,旨在丰富和提高两个参与机构的研究潜力和哮喘管理能力。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Georgia Dunston其他文献

Georgia Dunston的其他文献

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{{ truncateString('Georgia Dunston', 18)}}的其他基金

ADMIXTURE MAPPING OF HTN IN AA (AMHA)
AA (AMHA) 中 HTN 的混合图
  • 批准号:
    7951434
  • 财政年份:
    2009
  • 资助金额:
    $ 5.55万
  • 项目类别:
H/H-ASTHMA HGC
H/H-哮喘 HGC
  • 批准号:
    7378681
  • 财政年份:
    2006
  • 资助金额:
    $ 5.55万
  • 项目类别:
Engaging African Communities for the HapMap Project
让非洲社区参与单体型图项目
  • 批准号:
    6668505
  • 财政年份:
    2002
  • 资助金额:
    $ 5.55万
  • 项目类别:
Howard/Hopkins Center for Reducing Asthma Disparities
霍华德/霍普金斯减少哮喘差异中心
  • 批准号:
    6946805
  • 财政年份:
    2002
  • 资助金额:
    $ 5.55万
  • 项目类别:
Howard/Hopkins Center for Reducing Asthma Disparities
霍华德/霍普金斯减少哮喘差异中心
  • 批准号:
    7123011
  • 财政年份:
    2002
  • 资助金额:
    $ 5.55万
  • 项目类别:
HUMAN IMMUNOGENETIC LAB: HLA GENES IN BLACKS: EPIDEM: INTERNATL GENOME: PEDIGREE
人类免疫遗传学实验室:黑人 HLA 基因:流行病:内部基因组:谱系
  • 批准号:
    6355282
  • 财政年份:
    2000
  • 资助金额:
    $ 5.55万
  • 项目类别:
HUMAN IMMUNOGENETIC LAB: HLA GENES IN BLACKS: EPIDEM: INTERNATL GENOME: PEDIGREE
人类免疫遗传学实验室:黑人 HLA 基因:流行病:内部基因组:谱系
  • 批准号:
    6317965
  • 财政年份:
    1999
  • 资助金额:
    $ 5.55万
  • 项目类别:
HUMAN IMMUNOGENETIC LAB: HLA GENES IN BLACKS: EPIDEM: INTERNATL GENOME: PEDIGREE
人类免疫遗传学实验室:黑人 HLA 基因:流行病:内部基因组:谱系
  • 批准号:
    6318437
  • 财政年份:
    1999
  • 资助金额:
    $ 5.55万
  • 项目类别:
COORDINATING CTR AFRICA AMERICA DIABETES MELLITUS STUDY
协调 CTR 非洲美洲糖尿病研究
  • 批准号:
    6131210
  • 财政年份:
    1998
  • 资助金额:
    $ 5.55万
  • 项目类别:
COORDINATING CTR AFRICA AMERICA DIABETES MELLITUS STUDY
协调 CTR 非洲美洲糖尿病研究
  • 批准号:
    6159031
  • 财政年份:
    1998
  • 资助金额:
    $ 5.55万
  • 项目类别:

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