ADMIXTURE MAPPING OF HTN IN AA (AMHA)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目的目标是帮助我们了解非裔美国人高血压的遗传基础。高血压对再障的影响不成比例，其并发症极大地加剧了再障的健康差距，因为中风、心力衰竭、肾衰竭和冠心病的发病率增加。现在公认的是HTN是遗传和环境因素复杂相互作用的结果，但环境风险因素，包括生活方式、饮食和心理社会因素，比遗传因素更具特征。到目前为止，连锁和候选基因研究在不同研究和人群中取得的成功有限。 基于先前资助的华盛顿大都市地区再生障碍性贫血家庭遗传流行病学研究的成功，我们建议登记HTN病例和未受影响对照的人群样本，在样本中对一组祖先信息标记进行基因分型，并利用混合作图方法识别与HTN相关的基因组区域。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to contribute to our understanding of the genetic basis of hypertension(HTN) in African-Americans(AA). Hypertension disproportionately affects AA and its complications contribute immensely to health disparity experienced by AA through increased morbidity from stroke,heart failure, kidney failure and coronary heart disease. It is now accepted that HTN results from a complex interplay between genetic and environmental factors.However, the environmental risk factors, which include lifestyle, dietary and psycho-social factors, have been better characterized than the genetic ones. Linkage and candidate gene studies have so far provided limited success across studies and population groups. Building on the success of a previously funded study of the genetic epidemiology of AA families in the Washington DC metropolitan area, we propose to enroll a population sample of HTN cases and unaffected controls, genotype a panel of ancestry informative markers(AIM) in the sample and utilize the admixture mapping approach to identify genomic regions associated with HTN.