ROLE OF INFANT FEEDING IN CHILDHOOD ALLERGY

婴儿喂养在儿童过敏中的作用

• 批准号: 7607776
• 负责人: ARDYTHE L MORROW
• 金额: $ 2.28万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607776
• 关键词: Accounting; Age-Months; Asthma; Birth; Birth History; Blood specimen; Breast Feeding; Characteristics; Childhood; Computer Retrieval of Information on Scientific Projects Database; Consent; Data; Diet; Enrollment; Funding; Genotype; Grant; Home environment; Human Milk; Hypersensitivity; Hypersensitivity skin testing; Infant; Institution; Maternal Health; Milk; Mothers; Observational Study; Outpatients; Peripheral; Phenotype; Physicians; Postpartum Period; Questionnaires; Recording of previous events; Research; Research Personnel; Resources; Role; Sampling; Severities; Source; Symptoms; Telephone Interviews; Test Result; United States National Institutes of Health; Visit; Week; cytokine; feeding; follow-up; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Role of Infant Feeding in Childhood Allergy is a prospective observational study of asthmatic and non-asthmatic mothers and their infants enrolled within 2 weeks of birth and followed through 9-12 months postpartum. The aims of the study are to 1) compare the peripheral cytokine phenotypes of breastfed and non-breastfed infants between 9-12 months of age, accounting for maternal history of asthma, 2) compare the cytokine phenotypes of the milk of asthmatic and non-asthmatic mothers, and 3) examine the relationship between cytokine concentrations in maternal milk and the infants' peripheral cytokine phenotypes, accounting for maternal history of asthma and maternal and infant cytokine genotypes. Eligible mothers who consent to participate complete a baseline questionnaire at 2-3 weeks postpartum. Data related to maternal health history, birth history, infant feeding, maternal diet, and demographic characteristics is collected. A sample of human milk is collected at home from all breastfeeding mothers approximately 4-weeks postpartum. Monthly questionnaires are then completed for all subjects to collect data on infant and maternal illness, asthma severity symptoms, and infant feeding. All questionnaires are completed by telephone interview. At 9-12 months postpartum, a blood sample is collected for all mothers and infants during the one outpatient study visit. Allergy skin testing for the mother and her infant is also completed at this visit. Subjects are referred for follow-up with their physician or an allergist for any positive skin test results.

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 婴儿喂养在儿童过敏中的作用是一项前瞻性观察性研究，研究对象为出生后2周内入组的哮喘和非哮喘母亲及其婴儿，并随访至产后9-12个月。该研究的目的是1）比较9-12个月龄的母乳喂养和非母乳喂养的婴儿的外周细胞因子表型，说明母亲的哮喘史，2）比较哮喘和非哮喘母亲的乳汁的细胞因子表型，和3）检查母乳中的细胞因子浓度与婴儿的外周细胞因子表型之间的关系，解释了母亲的哮喘史和母亲和婴儿的细胞因子基因型。 同意参与的合格母亲在产后2-3周完成基线问卷。收集与产妇健康史、出生史、婴儿喂养、产妇饮食和人口统计学特征相关的数据。在产后约4周，从所有母乳喂养的母亲家中收集人乳样品。然后对所有受试者进行每月问卷调查，以收集有关婴儿和母亲疾病、哮喘严重程度症状和婴儿喂养的数据。所有问卷均以电话访问方式完成。在产后9-12个月，在一次门诊研究访问期间收集所有母亲和婴儿的血液样品。母亲和婴儿的过敏性皮肤测试也在这次访视中完成。受试者被转诊到他们的医生或过敏症专科医生处进行任何阳性皮肤试验结果的随访。