EFFECT OF SALICYLATE ON THE ALLERGIC PHENOTYPE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In vitro studies have shown that salicylates can effect transcription of cytokines and interkeukins such as down-regulation of IL-4 which is pivotal in the synthesis of IgE antibody and the development of the allergic phenotype. In humans, inhaled salicylates inhibit early and late asthmatic responses to allergen lung challenge. This is a preliminary study to explore the role of salicylate in the therapy of asthma and allergic disease. The hypothesis is that salicylate therapy will shift cytokine production and surface marker expression away from the allergic phenotype. The proposed work will lay the groundwork for future studies to understand the biologic and molecular basis of anti-allergic effect of salicylate treatment.