SURGICAL WEIGHT LOSS INTERVENTION IN SLEEP APNEA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 上呼吸道周期性阻塞是阻塞性睡眠呼吸暂停(OSA)最常见的原因。导致呼吸道塌陷性增加以及由此导致的阻塞性睡眠呼吸暂停的最大危险因素是肥胖。同样，众所周知，减肥可以降低阻塞性睡眠呼吸暂停综合症的严重性。到目前为止，还不清楚体重减轻和OSA改善之间是否存在剂量-反应关系。体重减轻导致的阻塞性睡眠呼吸暂停综合征改善的因素也有待阐明。本议定书的目标是： 1)确定睡眠障碍呼吸(SDB)与上呼吸道生理、人体测量和代谢参数之间的关系； 2)确定体重减轻程度与 A)睡眠呼吸障碍的严重程度 B)减轻体重后上呼吸道的溃散性降低 C)其他神经、代谢、人体测量和生理预测指标

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodic occlusion of the upper airway is the most common cause of obstructive sleep apnea (OSA). The strongest risk factor for the development of increased airway collapsibility, and consequent OSA, is obesity. Similarly, weight loss is known to decrease the severity of OSA. To date, it is not clear if there is a dose-response relationship between weight loss and improvement in OSA. The factors involved in weight loss-induced improvements in OSA also remain to be elucidated. The goals of the present protocol are to: 1)determine the association between sleep disordered breathing (SDB) and upper airway physiologic, anthropometric and metabolic parameters; 2)determine the relationship between the degree of weight loss and a)the severity of sleep disordered breathing b)decreases in upper airway collapsibility after weight loss c)other neural, metabolic, anthropometric and physiologic predictors