RELATIONS BETWEEN URINE AND SERUM MEASURES OF IRON STATUS

尿液和血清铁状态测量之间的关系

• 批准号: 7607481
• 负责人: RICHARD M ALLEN
• 金额: $ 0.07万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607481
• 关键词: Age; Computer Retrieval of Information on Scientific Projects Database; Data; Etiology; Excretory function; Funding; Gender; Grant; Hour; Institution; Iron; Measures; Numbers; Race; Relative (related person); Research; Research Personnel; Resources; Restless Legs Syndrome; Serum; Source; Time; United States National Institutes of Health; Urine; iron metabolism; receptor; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. These investigators have demonstrated that iron metabolism differs in subjects with Restless Leg syndrome (RLS). In a parallel study, these investigators are characterizing the mechanism of the relative iron deficiency observed in RLS and preliminary data implicate increased iron excretion as the etiology for reduced iron stores and the inability to maintain these stores. Preliminary data showed an unexpectedly strong relationship between 24 hour urinary iron excretion and night time transferring receptor (TfR) numbers. To confirm and better characterize the presumed inverse logarithmic relationship between iron excretion and serum TfR in normal controls, these investigators propose a descriptive study to analyze the 24 hour urine iron and serum TfR levels in 28 age, gender, and race-matched controls. These data will be used to establish the parameters of normal iron excretion and will be compared with the iron excretion observed in RLS subjects.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这些研究者表明，铁代谢在不安腿综合征（RLS）的受试者中有所不同。在一项并行的研究中，这些研究者正在表征RLS中观察到的相对铁缺乏的机制，初步数据暗示了铁的排泄量增加是减少铁储存的病因，并且无法维持这些存储。初步数据显示24小时尿铁排泄与夜间转移受体（TFR）数量之间存在意外的牢固关系。 为了确认并更好地表征正常对照中铁排泄与血清TFR之间假定的对数关系，这些研究者提出了一项描述性研究，以分析28岁年龄，性别和种族匹配的控制的24小时尿液和血清TFR水平。这些数据将用于建立正常铁排泄的参数，并将与在RLS受试者中观察到的铁排泄进行比较。