RELATIONS BETWEEN URINE AND SERUM MEASURES OF IRON STATUS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这些研究人员已经证明，不宁腿综合征（RLS）受试者的铁代谢不同。在一项平行研究中，这些研究人员正在描述RLS中观察到的相对缺铁的机制，初步数据表明铁排泄增加是铁储存减少和无法维持这些储存的病因。初步数据显示，24小时尿铁排泄量与夜间转移受体（TfR）数量之间存在出乎意料的密切关系。 为了证实和更好地表征正常对照组铁排泄和血清TfR之间的假定反对数关系，这些研究人员提出了一项描述性研究，以分析28名年龄、性别和种族匹配的对照组的24小时尿铁和血清TfR水平。这些数据将用于确定正常铁排泄的参数，并与RLS受试者中观察到的铁排泄进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. These investigators have demonstrated that iron metabolism differs in subjects with Restless Leg syndrome (RLS). In a parallel study, these investigators are characterizing the mechanism of the relative iron deficiency observed in RLS and preliminary data implicate increased iron excretion as the etiology for reduced iron stores and the inability to maintain these stores. Preliminary data showed an unexpectedly strong relationship between 24 hour urinary iron excretion and night time transferring receptor (TfR) numbers. To confirm and better characterize the presumed inverse logarithmic relationship between iron excretion and serum TfR in normal controls, these investigators propose a descriptive study to analyze the 24 hour urine iron and serum TfR levels in 28 age, gender, and race-matched controls. These data will be used to establish the parameters of normal iron excretion and will be compared with the iron excretion observed in RLS subjects.