UTILITY OF ASSESSING TSH RECEPTOR ANTIBODY IN GRAVES' DISEASE
评估 TSH 受体抗体在格雷夫斯病中的效用
基本信息
- 批准号:7607279
- 负责人:
- 金额:$ 4.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-04-01 至 2008-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAffectBiological AssayChildClinicalClonalityComputer Retrieval of Information on Scientific Projects DatabaseDiagnosisDiseaseDisease ProgressionEnzyme-Linked Immunosorbent AssayFc ReceptorFundingGrantGraves&apos DiseaseHeterogeneityHormonalHyperthyroidismIndividualInstitutionMeasuresMedicalNewly DiagnosedPatientsResearchResearch PersonnelResourcesSeveritiesSourceTSH receptor antibodyThyroid Function TestsThyrotropin ReceptorUnited States National Institutes of Health
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The objectives of this proposal will be to:
1) Prospectively follow a group of children and adolescents with newly diagnosed Graves' disease
2) Measure thyroid function tests (T4, Free T4, Total T3, and TSH), TSH receptor antibodies (by both ELISA and bioassay), and TSH receptor antibody oligoclonality (as assessed by lambda/kappa ratio) at diagnosis, 6 months, and 12 months
3) Determine whether initial severity of hyperthyroidism (as determined by both clinical and hormonal parameters) is related to initial TSH receptor Ab potency and/or oligoclonality or both
4) Determine whether TSH receptor Ab titer at 6 months and at 12 months is related to:
a) initial severity of hyperthyroidism (as determined by both clinical and hormonal parameters)
b) initial TSH receptor Ab potency (by both ELISA and bioassay)
c) initial TSH receptor Ab oligoclonality, as well as TSH receptor Ab oligoclonality at 6 months and 12 months
5) Characterize the course of TSH receptor Ab heterogeneity at diagnosis, 6 months and 12 months in individual patients;
We hypothesize that:
1) Amongst children with Graves' disease, 75% will have TSH receptor Abs that are polyclonal as assessed by lambda/kappa ratio and 25% will have oligoclonal Abs
2) Oligoclonal Abs are more potent and affected patients have more severe disease and are less likely to remit
3) Those patients who have the most severe disease at diagnosis will have the highest TSH receptor Ab titers and will be less likely to remit on medical therapy
4) 25% of patients will have a change in clonality with disease progression.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
本提案的目标是:
1)一组新诊断的Graves病儿童和青少年的随访结果
2)在诊断、6个月和12个月时测量甲状腺功能测试(T4、游离T4、总T3和TSH)、TSH受体抗体(通过ELISA和生物测定)和TSH受体抗体寡克隆性(通过λ/κ比值评估)
3)确定甲状腺功能亢进症的初始严重程度(由临床和激素参数确定)是否与初始TSH受体Ab效力和/或寡克隆性或两者相关
4)确定6个月和12个月时TSH受体Ab滴度是否与以下因素相关:
a)甲状腺功能亢进症的初始严重程度(由临床和激素参数确定)
B)初始TSH受体Ab效力(通过ELISA和生物测定)
c)初始TSH受体Ab寡克隆性,以及6个月和12个月时的TSH受体Ab寡克隆性
5)描述个体患者诊断时、6个月和12个月时TSH受体Ab异质性的过程;
我们假设:
1)在Graves病儿童中,75%的TSH受体抗体是多克隆的(根据λ/κ比值评估),25%的是寡克隆抗体
2)寡克隆抗体更有效,受影响的患者病情更严重,不太可能缓解
3)诊断时病情最严重的患者TSH受体抗体滴度最高,不太可能接受药物治疗
4)25%的患者随着疾病进展克隆性发生变化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Rosalind Brown其他文献
Rosalind Brown的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Rosalind Brown', 18)}}的其他基金
PREDICTION OF REMISSION IN CHILDREN AND ADOLESCENTS WITH GRAVES' DISEASE: UTILIT
患有格雷夫斯病的儿童和青少年的缓解预测:UTILIT
- 批准号:
7380771 - 财政年份:2006
- 资助金额:
$ 4.2万 - 项目类别:
THYROID IMMUNOLOGLOBULINS IN SPORADIC NON-TOXIC GOITER
散发性非毒性甲状腺肿中的甲状腺免疫球蛋白
- 批准号:
3152953 - 财政年份:1984
- 资助金额:
$ 4.2万 - 项目类别:
THYROID IMMUNOLOGLOBULINS IN SPORADIC NON-TOXIC GOITER
散发性非毒性甲状腺肿中的甲状腺免疫球蛋白
- 批准号:
3232199 - 财政年份:1984
- 资助金额:
$ 4.2万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 4.2万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 4.2万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 4.2万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 4.2万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 4.2万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 4.2万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 4.2万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 4.2万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 4.2万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 4.2万 - 项目类别:
Studentship