AMILORIDE FOR ERADICATION OF BURKHOLDERIA DOLOSA

阿米洛利用于根除伯克霍尔德氏菌

• 批准号: 7607305
• 负责人: DAWN A ERICSON
• 金额: $ 1.66万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607305
• 关键词: Amiloride; Breathing; Burkholderia; Computer Retrieval of Information on Scientific Projects Database; Count; Dose; Funding; Grant; Incidence; Inflammatory; Institution; Lung; Quality of life; Research; Research Personnel; Resources; Respiratory Tract Infections; Safety; Score; Solutions; Source; Sputum; Tobramycin; United States National Institutes of Health; Weight Gain; cystic fibrosis patients; pulmonary function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Objective: Determination of the ability of multiple doses of amiloride solution for inhalation (ASI) and tobramycin solution for inhalation (TSI) to eradicate Burkholderia dolosa respiratory tract infection in patients with cystic fibrosis. Secondary Objectives: 1. Determination of the safety and tolerability of multiple doses of ASI and TSI in patients with cystic fibrosis and Burkholderia dolosa respiratory tract infection. 2. To obtain evidence of efficacy of multiple doses of ASI and TSI in patients with cystic fibrosis and Burkholderia dolosa respiratory tract infection as reflected in a change in pulmonary function, expectorated sputum bacterial colony counts, incidence of pulmonary exacerbations, weight gain, quality of life scores, and inflammatory markers.

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