ANTI-IGA ANTIBODIES WITH ADVERSE REACTIONS TO GAMMA GLOBULIN INFUSION

对丙种球蛋白输注有不良反应的抗 IGA 抗体

• 批准号: 7607296
• 负责人: FRACISCO A BONILLA
• 金额: $ 0.07万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607296
• 关键词: Adverse reactions; Antibodies; Boston; Computer Retrieval of Information on Scientific Projects Database; Enzyme-Linked Immunosorbent Assay; Funding; Gamma globulin; Grant; IgE; Immunoglobulin A; Immunoglobulin G; Immunologic Deficiency Syndromes; Infusion procedures; Institution; Methods; Patients; Pediatric Hospitals; Pilot Projects; Research; Research Personnel; Resources; Serum; Source; United States National Institutes of Health; anti-IgA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A. Specific Aims /Objectives 1. To conduct a pilot study at Children's Hospital Boston of a possible correlation between the presence of serum IgG or IgE anti-IgA antibodies in IgA-deficient patients and the occurrence of adverse reactions to gamma globulin administration in patients with primary immunodeficiency. 2. To compare results of ELISA methods for the determination of IgG anti-IgA antibodies with commercially available passive hemaglutination and immunoradiometric methods. 3. To examine the persistence of anti-IgA antibodies over a 6 month period.

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