INFLAMMATORY GENE POLYMORPHISMS IN CARDIAC SURGERY

心脏手术中的炎症基因多态性

• 批准号: 7607246
• 负责人: CATHERINE ALLAN
• 金额: $ 4.34万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607246
• 关键词: Blood capillaries; Cardiac Surgery procedures; Cardiopulmonary Bypass; Clinical; Coagulation Process; Computer Retrieval of Information on Scientific Projects Database; Condition; Functional disorder; Funding; Genes; Genetic Polymorphism; Grant; Inflammatory; Inflammatory Response; Institution; Mediator of activation protein; Morbidity - disease rate; Observational Study; Production; Research; Research Personnel; Resources; Sepsis; Source; United States National Institutes of Health; base; body system; capillary; cytokine; infant outcome; leukocyte activation; mortality; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiopulmonary bypass (CPB) is a potent trigger of the systemic inflammatory response, which includes activation of leukocytes and production of multiple pro-inflammatory mediators. Its consequences include multi-organ system dysfunction, capillary leak, altered coagulation, and increased morbidity and mortality. In sepsis, a condition in which the inflammatory response shares mechanistic and clinical similarities to that seen with CPB, polymorphisms of specific inflammatory genes have been associated with alterations in inflammatory cytokine production and increased mortality. Based upon this information, we propose a prospective observational study to investigate the relationship between inflammatory gene polymorphisms, production of circulating inflammatory mediators, and clinical outcome for infants undergoing cardiac surgery with CPB.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 心脏搭桥术（CPB）是全身炎症反应的有效触发器，其包括白细胞活化和多种促炎介质的产生。其后果包括多器官系统功能障碍、毛细血管渗漏、凝血改变以及发病率和死亡率增加。脓毒症是一种炎症反应与CPB具有机制和临床相似性的疾病，特定炎症基因的多态性与炎症细胞因子产生的改变和死亡率增加相关。基于这些信息，我们提出了一项前瞻性观察性研究，以调查炎症基因多态性，循环炎症介质的产生，以及接受CPB心脏手术的婴儿的临床结局之间的关系。