DYSPRAXIA AND AUTONOMIC CONTROL IN VERY EARLY AD

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 阿尔茨海默氏痴呆症只是长达数十年的心理过程的最后阶段。 在临床医生发现痴呆之前，AD病理可能已经到达岛叶皮质，这与心率和血压的自主控制有关。 岛状病变，尤其是右侧的岛状病变，与缓慢心律失常、心率变异性降低和死亡率增加有关。 临床前 AD 应被视为非痴呆老年人心血管/跌倒相关发病率和死亡率的可能解释。 该研究将研究右半球功能障碍与三个认知障碍水平的自主控制之间的关联。 所有受试者都没有明显的心脏病。 右半球功能将通过结构实践的测量来评估，并通过功能性 MRI 来评估区域脑血流量。 自主控制将通过对 24 份动态心电图记录得出的 HRV 进行统计分析来评估，并辅以所选心律失常的频率和严重程度、直立性血压和症状自我报告。 受试者为年龄 75 岁或以上的男性和女性非收容老年人。 将包括正常对照、符合“轻度认知障碍”(MCI) 标准的认知障碍受试者以及轻度 AD 病例。 受试者将接受解剖和功能 MRI 检查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Alzheimer's dementia is merely the final stage of a psychological process that spans decades. Before clinicians can detect dementia, AD pathology may have already reached the insular cortex, which is related to autonomic control of heart rate and blood pressure. Insular lesions, particularly on the right, are associated with bradyarrhythmias, decreased heart rate variability and increased mortality. Preclinical AD should be considered as a possible explanation for cardiovascular/fall related morbidity and mortality in non-demented elderly persons. The study will examine the association between right hemisphere dysfunction and autonomic control at three levels of cognitive impairment. All subject will be free of significant cardiac disease. Right hemisphere function will be assessed by measures of constructional praxis, and regional cerebral blood flow by functional MRI. Autonomic control will be assessed by statistical analyses of HRV derived from 24 Holter records, supplemented by the frequency and severity of selected cardiac arrhythmias, orthostatic blood pressure, and symptom self-reports. Subjects will be male and female non-institutionalized elderly persons, aged 75 years or older. Normal controls, cognitively impaired subjects meeting criteria for "Mild Cognitive Impairment" (MCI), and cases with mild AD will be included. Subjects will have anatomical and functional MRI.