DYSPRAXIA AND AUTONOMIC CONTROL IN VERY EARLY AD

公元早期的运用障碍和自主控制

• 批准号: 7378223
• 负责人: DONALD R ROYALL
• 金额: $ 0.31万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378223
• 关键词: DYSPRAXIA; AUTONOMIC; CONTROL; VERY; EARLY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Alzheimer's dementia is merely the final stage of a psychological process that spans decades. Before clinicians can detect dementia, AD pathology may have already reached the insular cortex, which is related to autonomic control of heart rate and blood pressure. Insular lesions, particularly on the right, are associated with bradyarrhythmias, decreased heart rate variability and increased mortality. Preclinical AD should be considered as a possible explanation for cardiovascular/fall related morbidity and mortality in non-demented elderly persons. The study will examine the association between right hemisphere dysfunction and autonomic control at three levels of cognitive impairment. All subject will be free of significant cardiac disease. Right hemisphere function will be assessed by measures of constructional praxis, and regional cerebral blood flow by functional MRI. Autonomic control will be assessed by statistical analyses of HRV derived from 24 Holter records, supplemented by the frequency and severity of selected cardiac arrhythmias, orthostatic blood pressure, and symptom self-reports. Subjects will be male and female non-institutionalized elderly persons, aged 75 years or older. Normal controls, cognitively impaired subjects meeting criteria for "Mild Cognitive Impairment" (MCI), and cases with mild AD will be included. Subjects will have anatomical and functional MRI.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。阿尔茨海默氏症只是一个跨越数十年的心理过程的最后阶段。在临床医生发现痴呆症之前，AD的病理可能已经到达岛叶皮质，这与自主控制心率和血压有关。岛状病变，特别是右侧，与缓慢性心律失常、心率变异性降低和死亡率增加有关。临床前AD应该被认为是非痴呆老年人心血管/跌倒相关发病率和死亡率的可能解释。这项研究将在认知障碍的三个水平上检查右脑功能障碍和自主神经控制之间的联系。所有受试者都不会患上严重的心脏病。右脑功能采用功能磁共振检查，右脑功能评定采用构造性活动测量。自主控制将通过对来自24个Holter记录的HRV的统计分析进行评估，并辅之以选定的心律失常、立位血压和症状自我报告的频率和严重程度。研究对象将是75岁或以上的男性和女性非住院老人。包括正常对照组、符合“轻度认知障碍”(MCI)标准的认知受损受试者，以及患有轻度AD的患者。受试者将接受解剖和功能核磁共振检查。