(EDIC)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究跟踪了已经通过糖尿病控制和并发症试验（DCCT）治疗和评估的患者。 DCCT中随访的所有患者都被要求参加Joslin糖尿病中心和北美其他28个中心的这项研究。 该项目的总体目标是检查与大血管、视网膜病变、肾病和神经病变并发症的发展相关的因素。 这是一项自然史研究，因此将对所有志愿者进行10年随访，而不考虑DCCT试验中分配的治疗状态。研究的主要目的包括： 1)胰岛素依赖型糖尿病患者动脉粥样硬化性心血管疾病长期病程的测定 2)研究潜在危险因素（包括非糖尿病和胰岛素依赖型糖尿病人群中确定的危险因素）对胰岛素依赖型糖尿病心血管疾病发生和进展的影响 3)研究已确定特征的IDDM人群中微量白蛋白尿和临床肾病的长期演变 4)检查早期糖尿病治疗（常规vs.强化）对肾病和神经病变后续发展和进展的长期影响。 5)研究美国和加拿大随时间推移为胰岛素依赖型糖尿病患者提供的医疗保健。 每年对患者进行随访，以评估心血管、外周血管、神经病、视网膜病、代谢和医疗保健提供问题。 此外，研究者团队将每两年对患者进行一次心理和饮食问卷评估，并将在随机化进入DCCT试验的第8、12和16周年时接受眼底照片。 最后，将通过电话访谈每季度收集一次低血糖数据，并通过标准化的面对面访谈每年收集一次。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study follows patients already treated and evaluated through the Diabetes Control and Complications Trial (DCCT). All patients followed in the DCCT were asked to participate in this study at Joslin Diabetes Center and the other 28 centers in North America. The overall goal of the project is to examine factors associated with the development of macrovascular, retinopathic, nephropathic, and neuropathic complications of IDDM, or Type 1 diabetes. This is a natural history study so that all volunteers will be followed for 10 years without regard to assigned treatment status in the DCCT trial. The major objectives of the study include: 1) Determination of the long term course of atherosclerotic cardiovascular disease in IDDM 2) To study the effects of potential risk factors including those established in non-diabetic and IDDM populations on the development and progression of cardiovascular disease in IDDM 3) To study the long term evolution of microalbuminuria and clinical nephropathy in an already characterized population of persons with IDDM 4) To examine the long term effects of early diabetes treatment (conventional vs. intensive) on subsequent development and progression of nephropathy and neuropathy. 5) To study the health care provided to IDDM patients in the US and Canada over time. Patients will be followed annually for assessment of cardiovascular, peripheral vascular, neuropathic, retinopathic, metabolic, and health care delivery issues. In addition, patients will be evaluated on psychological and dietary questionnaires bi-annually by the investigator team and will receive fundus photographs on the 8th, 12th and 16th anniversary of randomization into the DCCT trial. Finally, hypoglycemic data will be gathered quarterly through telephone interviews and through a standardized face to face interview on an annual basis.