(EDIC)

(EDIC)

• 批准号: 7718955
• 负责人: ALAN M JACOBSON
• 金额: $ 0.28万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718955
• 关键词: Anniversary; Atherosclerosis; Blood Vessels; Canada; Cardiovascular Diseases; Cardiovascular system; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diabetes Mellitus; Dietary Questionnaires; Evolution; Face; Funding; Fundus; Goals; Grant; Healthcare; Hypoglycemia; Hypoglycemic Agents; Institution; Insulin-Dependent Diabetes Mellitus; Interview; Kidney Diseases; Long-Term Effects; Longitudinal Studies; Metabolic; Microalbuminuria; Natural History; Neuropathy; North America; Patients; Peripheral; Persons; Population; Randomized; Research; Research Personnel; Resources; Risk Factors; Source; Telephone Interviews; Time; United States National Institutes of Health; base; health care delivery; non-diabetic; psychologic; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study follows patients already treated and evaluated through the Diabetes Control and Complications Trial (DCCT). All patients followed in the DCCT were asked to participate in this study at Joslin Diabetes Center and the other 28 centers in North America. The overall goal of the project is to examine factors associated with the development of macrovascular, retinopathic, nephropathic, and neuropathic complications of IDDM, or Type 1 diabetes. This is a natural history study so that all volunteers will be followed for 10 years without regard to assigned treatment status in the DCCT trial. The major objectives of the study include: 1) Determination of the long term course of atherosclerotic cardiovascular disease in IDDM 2) To study the effects of potential risk factors including those established in non-diabetic and IDDM populations on the development and progression of cardiovascular disease in IDDM 3) To study the long term evolution of microalbuminuria and clinical nephropathy in an already characterized population of persons with IDDM 4) To examine the long term effects of early diabetes treatment (conventional vs. intensive) on subsequent development and progression of nephropathy and neuropathy. 5) To study the health care provided to IDDM patients in the US and Canada over time. Patients will be followed annually for assessment of cardiovascular, peripheral vascular, neuropathic, retinopathic, metabolic, and health care delivery issues. In addition, patients will be evaluated on psychological and dietary questionnaires bi-annually by the investigator team and will receive fundus photographs on the 8th, 12th and 16th anniversary of randomization into the DCCT trial. Finally, hypoglycemic data will be gathered quarterly through telephone interviews and through a standardized face to face interview on an annual basis.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究跟踪了已经通过糖尿病控制和并发症试验(DCCT)进行治疗和评估的患者。所有接受DCCT的患者都被要求在Joslin糖尿病中心和北美的其他28个中心参与这项研究。该项目的总体目标是检查与IDDM或1型糖尿病的大血管、视网膜病变、肾病和神经病变并发症的发展相关的因素。这是一项自然历史研究，因此所有志愿者将被跟踪10年，而不考虑在DCCT试验中分配的治疗状态。研究的主要目标包括： 1)IDDM患者动脉粥样硬化性心血管疾病长期病程的测定 2)研究潜在危险因素，包括那些在非糖尿病和IDDM人群中存在的因素，对IDDM心血管疾病的发生和发展的影响。 3)研究IDDM患者中微量白蛋白尿和临床肾病的长期演变 4)研究早期糖尿病治疗(常规治疗和强化治疗)对肾病和神经病变的后续发展和进展的长期影响。 5)研究美国和加拿大一段时间以来为IDDM患者提供的医疗保健。 每年将对患者进行跟踪，以评估心血管、外周血管、神经病变、视网膜病变、代谢和医疗保健提供问题。此外，研究小组将每两年对患者进行一次心理和饮食问卷评估，并将在随机进入DCCT试验8、12和16周年时收到眼底照片。最后，将通过电话采访和标准化的面对面采访每年收集每季度的降糖数据。