METABOLIC CORRELATES OF OBSTRUCTIVE SLEEP APNEA IN OBESE CHILDREN

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is a common problem in the pediatric population with a prevalence of 16%. Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a pattern of recurrent hypoxemia and occurs in 1/3 of obese children. In adults, visceral adiposity predicts both OSAHS and the metabolic syndrome. OSAHS itself has been associated with insulin resistance and inflammation. Our goal is to investigate the metabolic correlates of OSAHS in obese children by examining insulin resistance, inflammation, and body fat distribution.