ALZHEIMER'S DISEASE GENETICS INITIATIVE: THE MULTIPLEX FAMILY STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 NIA遗传学倡议：多元化家庭研究的目的是确定有多个成员被诊断为晚发性阿尔茨海默病的家庭。将对家庭进行临床鉴定，并收集血液样本以建立细胞系。如果没有血液样本，将收集身体样本进行DNA提取和储存。我们的目标是在三年内招收1000个家庭。这些家庭的临床和人口学数据将在当地网站收集，没有识别符的编码数据将被发送并纳入阿尔茨海默病家庭的国家数据库。这个数据库和生物样本一起，将存放在印第安纳大学的阿尔茨海默病国家细胞库(NCRAD)。来自这些家庭的生物样本和数据将提供给合格的研究人员，他们必须在收到DNA和数据之前签署材料转让协议。监督委员会被称为细胞库咨询委员会(CBAC)，将审查和监测家庭识别和登记、数据收集、细胞系的建立和样本获取的过程。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the NIA Genetics Initiative: Multiplex Family Study is to identify families with multiple members diagnosed with late-onset Alzheimer's Disease. Families will be characterized clinically and blood samples will be collected to establish cell lines. If a blood sample is not available, autopsy samples will be collected for DNA extraction and storage. Our goal is to recruit 1,000 families in three years. Clinical and demographic data from these families will be collected at the local site and coded data, without identifiers, will be sent and included in a national database of families with Alzheimer's Disease. This database, along with biological samples, will be housed at the National Cell Repository for Alzheimer's Disease (NCRAD) at Indiana University. The biological samples and data from these families will be available to qualified researchers, who must sign a Material Transfer Agreement before receiving DNA and data. An oversight committee knows as the Cell Bank Advisory Committee (CBAC) will review and monitor the process of family identification and enrollment, data collection, the establishment of cell lines and access to samples.