CONTRIBUTION OF INSULIN TO POST EXERCISE HYPOTENSION

胰岛素对运动后低血压的影响

• 批准号: 7625843
• 负责人: ELLEN SPILLER
• 金额: $ 1.63万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625843
• 关键词: Blood; Blood Pressure; Blood Vessels; Computer Retrieval of Information on Scientific Projects Database; Drops; Exercise; Funding; Grant; Hyperinsulinism; Hypotension; Institution; Insulin; Measurement; Measures; Octreotide; Physiological; Regression Analysis; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Vascular resistance; Vasodilator Agents; Woman; insulin secretion; men; normotensive; somatostatin analog

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Post exercise hypotension is described as a 5-10 mmHg drop in BP after a single bout of dynamic exercise at 50-60% VO2max elicited after 30-60 min or 75% VO2max for 15- 30 minutes in normotensive men and women. This is due to a persistent rise in vascular conductance and drop in vascular resistance without being offset by a matched increase in Q. PEH is currently attributed to an 'unknown vasodilator.' Additionally, physiological hyperinsulinemia is known to have a vasodilatory effect. This proposal seeks to identify the effects of insulin on post exercise hypotension by using physiological stimulation of insulin secretion, exercise, and pharmacological inhibition of insulin secretion. We postulate that high intensity exercise inhibits insulin secretion leading to a post exercise insulin surge contributing to post exercise hypotension. Accordingly, we will determine achieved hypotension post exercise in a group of normally fit young men and women and relate it to blood insulin concentration. We will then manipulate insulin concentration by infusing a somatostatin analogue, Octreotide, inhibiting insulin secretion, and measure changes in blood pressure. Regression analysis will be used to determine the relationship between blood pressure and insulin concentration. Analysis of variables will be used to determine shifts in blood pressure due to experimental manipulation (octreotide or sham). The Bland-Altman approach will be used to determine repeatability of measurements.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 运动后低血压被描述为在血压正常的男性和女性中，在30-60分钟后以50- 60%VO2max或75%VO2max进行15- 30分钟的单次动态运动后BP下降5-10 mmHg。 这是由于血管电导的持续上升和血管阻力的下降，而没有被Q的匹配增加所抵消。 PEH目前归因于一种未知的血管扩张剂。此外，生理性高胰岛素血症已知具有血管舒张作用。 该提案旨在通过使用胰岛素分泌的生理刺激、运动和胰岛素分泌的药理学抑制来确定胰岛素对运动后低血压的影响。 我们推测，高强度运动抑制胰岛素分泌，导致运动后胰岛素激增，从而导致运动后低血压。 因此，我们将确定一组正常健康的年轻男性和女性在运动后达到的低血压，并将其与血液胰岛素浓度联系起来。 然后，我们将通过输注生长抑素类似物奥曲肽来控制胰岛素浓度，抑制胰岛素分泌，并测量血压的变化。 回归分析将用于确定血压和胰岛素浓度之间的关系。 变量分析将用于确定实验操作（奥曲肽或假手术）引起的血压变化。 将使用Bland-Altman方法确定测量的重复性。