VASCULAR HEALTH IN ADOLESCENT GIRLS: AN ULTRASOUND STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该提案的目标是开发一个R01应用到美国国立卫生研究院(NHLBI、NICHD或NIDDK)，以探索与青少年血管功能障碍相关的行为和生物学变化的模式。为此，这里提出的研究将在一项关于体重、饮食习惯和肥胖症的纵向研究(The Girls‘Need Study，Leann L.Birch，PI，5R01HD032973-10)的青春期女孩子集中检查这些关系。尽管动脉粥样硬化在儿童中并不常见，但尸检研究已经证实，脂肪条纹(斑块发展的前兆)在3岁的儿童中很明显[1]。然而，对健康儿童血管功能障碍的危险因素知之甚少，因为测量斑块发展最早步骤的技术是侵入性的。在这个项目中，我们将使用超声波测量参加女孩需要项目(n=168)的一组青春期女孩(n=60)的血管功能。因此，我们建议伯奇博士(人类发展和家庭研究)和韦斯特博士(生物行为健康)进行一项跨学科研究，这将使我们能够测试新的假设，如果没有这种合作努力，这些假设是无法解决的。在过去的10年里，伯奇博士的团队收集了大量关于女孩饮食模式、节食态度、体重、身体成分和家族史的发育变化的记录。此外，女孩们将首次提供全血样本，用于分析炎症标志物和代谢综合征的临床成分，包括葡萄糖、胰岛素和血脂。这将使我们能够测试有全身炎症和/或代谢综合征证据的女孩是否表现出异常的血管功能，并检查体重或饮食习惯的发育变化是否与血管健康的标志有关。这项研究将使我们能够证明我们可以在青少年中成功地进行这些测量，它将提供一个异常丰富的机会来测试关于心血管风险的发育假说。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this proposal is to develop an R01 application to the National Institutes of Health (NHLBI, NICHD, or NIDDK) to explore patterns of behavioral and biological changes that are associated with vascular dysfunction in adolescents. To that end, the study proposed here will examine these relationships in a subset of adolescent girls enrolled in a longitudinal study of body weight, eating habits and obesity (The Girls' NEEDS Study, Leann L. Birch, PI, 5R01HD032973-10). Although atherosclerosis is not commonly diagnosed in children, autopsy studies have confirmed that fatty streaks (precursors of plaque development) are evident in children as young as 3 years of age [1]. However, little is known about risk factors for vascular dysfunction in healthy children because techniques for measuring the earliest steps in plaque development are invasive. In this project, we will use ultrasound to measure vascular function in a subgroup of adolescent girls (n = 60) who are enrolled in the Girls' NEEDS project (n = 168). Thus, we propose an interdisciplinary study between Dr. Birch (Human Development and Family Studies) and Dr. West (Biobehavioral Health) that will permit us to test new hypotheses that could not be addressed without this collaborative effort. Over the last 10 years, Dr. Birch's team has collected extensive records on developmental changes in the girls' dietary patterns, attitudes toward dieting, body weight, body composition, and family history. In addition, for the first time, the girls will provide whole blood samples for analysis of inflammatory markers and clinical components of the metabolic syndrome, including glucose, insulin, and the lipid profile. This will allow us to test whether girls with evidence of systemic inflammation and/or metabolic syndrome exhibit abnormal vascular function, and to examine whether developmental changes in body weight or eating habits are associated with markers of vascular health. This study will allow us to demonstrate that we can successfully conduct these measurements in adolescents, and it will provide an unusually rich opportunity to test developmental hypotheses about cardiovascular risk.