TIME SERIES MODELING TECHNIQUES FOR OPTIMAL GLYCEMIC CONTROL IN TYPE 1 DIABETES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目标是应用最佳控制技术，开发和测试一个监测特定结果（控制血糖水平）的程序，以个体为基础，用于I型糖尿病患者的样本。时间序列建模技术已被工程师用于确保制造过程中的最佳结果。 这种模式可以适应医学的需要，以增加干预措施的积极成果，这将计划在未来的研究。 基本上，建立用于确定良好结果的标准（葡萄糖水平的最佳范围）。 定期测量以监测结果。 如果结果朝着不希望的方向发展，则修改干预的水平或内容。 在下一次测量时，检查结果的方向以进行改进。 可以进行额外的修改以将结果向所需的方向移动。 与许多其他干预战略不同，干预的程度或内容可以根据个人情况进行调整。众所周知，药物和标准剂量并不对每个人都同样有效。 该计划将告知医生需要调整或继续维持特定药物和剂量。这种药物监测计划将不同于其他人，因为它量身定制的治疗需要和个人的反应。它还将通过频繁的饮食和运动评估来了解。调整饮食和运动的建议将与药物调整一起进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal is the application of optimal control techniques to develop and test a program of monitoring specified outcomes (controlled glucose level) on an individual basis for a sample of patients with Type I Diabetes. Time series modeling techniques have been used by engineers to ensure the best possible outcomes in manufacturing processes. Such models can be adapted to the needs of medicine to increase the positive results of interventions, which will be planned for future research studies. Basically, a criterion for determining a good outcome (optimal range of glucose level) is established. Regular measurements are taken to monitor the outcome. If the outcome is moving in an undesired direction, the level or content of the intervention is modified. At the next measurement occasion, the direction of the outcome is checked for improvement. Additional modifications can be made to move the outcome in the desired direction. Unlike many other intervention strategies, the degree or content of the intervention can be adjusted on an individual basis. It is well-known that medications and standard dosages do not work equally well for everyone. This program would inform the practitioner of a need for adjustment or continued maintenance of a particular medicine and dosage. This medication monitoring program will differ from others in that it tailors the treatment to the needs and responses of the individual. It also will be informed by frequent dietary and exercise assessments. Adjustments in recommendations regarding diet and exercise will be made in conjunction with the medication adjustments.