STRESS RESPONSE TO NON-WEIGHT BEARING BEDREST

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although immobility is known to be a major stressor that contributes to the incidence of adverse health events, the opportunity for nurses to study immobility in the absence of confounding co-morbid conditions is limited. The ability to isolate the stressful effect of immobility from the stressful effect of co-morbid conditions is the major strength of this proposed study. The primary purpose of this longitudinal repeated measures study is to examine the stress response of non-weight bearing bedrest over time in a sample of healthy volunteers. A secondary purpose is to examine the effect of bed rest on sleep patterns, fatigue, depression, discomfort, and pain. Bed rest has been associated with decline in functional ability, depression, institutionalization, and death in hospitalized patients. Several studies have found that immobility due to disease, trauma, or forced bed rest is a common occurrence, and a significant percentage of patients who enter a hospital will experience a decline in mobility and a reduction in their ability to manage activities of daily living (ADLS) as a direct result of bed rest. Bed rest is not an isolated event related to immobility and non-weight bearing; but rather a seminal event that begins a cascade of experiences and conditions that require constant physical, emotional, and social adjustment. The stress response to bed rest is a reaction to this cascading series of experiences and conditions. Even in previously healthy individuals, bed confinement in conjunction with perceptual deprivation leads to a loss of strength, energy, and motivation; increased fatigue and sleep disturbances; discomfort, and alterations in mood and circadian rhythms. Understanding psychoneuroimmune pattern changes over time in healthy volunteers receiving mechanical load replacement and supplementation during bedrest and those who do not may have profound implications for individuals with a variety of chronic debilitating disorders; and may lead to the development of preventive, primary and secondary nursing interventions to prevent or delay the adverse effects of bedrest. This study will extend knowledge of the effects of bed rest by examining changes in patterns of bed rest related symptoms, as well as diurnal patterns of HPA and ANS activation in a sample of healthy volunteers. In this study, we will recruit subjects from a sample of healthy volunteers enrolled in the Dr. Peter R. Cavanagh study titled: A Quantitative Test of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bed Rest Analogue. The research by Dr. Cavanagh is sponsored by the National Aeronautics and Space Administration (NASA) and will be performed at the Lerner Research Institute in the Department of Biomedical Engineering and the Cleveland Clinic General Clinical Research Center (GCRC). We obtained support for our sub-study from Dr. Cavanagh study entitled: A Quantitative Tes of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bed Rest Analogue. His research is sponsored by the National Aeronautics and Space Administration (NASA) and will be performed at the Lerner Research Institute in the Department of Biomedical Engineering and the Cleveland Clinic General Clinical Research Center (GCRC). We obtained support for our sub-study from Dr. Cavanagh.