STRESS RESPONSE TO NON-WEIGHT BEARING BEDREST

对非负重卧床的应激反应

• 批准号: 7377729
• 负责人: Sandra Lee Siedlecki
• 金额: $ 4.41万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377729
• 关键词: STRESS; RESPONSE; NON; WEIGHT; BEARING

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abstract: Although immobility is known to be a major stressor that contributes to the incidence of adverse health events, the opportunity for nurses to study immobility in the absence of confounding co-morbid conditions is limited. The ability to isolate the stressful effect of immobility from the stressful effect of co-morbid conditions is the major strength of this proposed study. The primary purpose of this longitudinal repeated measures study is to examine the stress response of non-weight bearing bedrest over time in a sample of healthy volunteers. A secondary purpose is to examine the effect of bed rest on sleep patterns, fatigue, depression, discomfort, and pain. Bed rest has been associated with decline in functional ability, depression, institutionalization, and death in hospitalized patients. Several studies have found that immobility due to disease, trauma, or forced bed rest is a common occurrence, and a significant percentage of patients who enter a hospital will experience a decline in mobility and a reduction in their ability to manage activities of daily living (ADLS) as a direct result of bed rest. Bed rest is not an isolated event related to immobility and non-weight bearing; but rather a seminal event that begins a cascade of experiences and conditions that require constant physical, emotional, and social adjustment. The stress response to bed rest is a reaction to this cascading series of experiences and conditions. Even in previously healthy individuals, bed confinement in conjunction with perceptual deprivation leads to a loss of strength, energy, and motivation; increased fatigue and sleep disturbances; discomfort, and alterations in mood and circadian rhythms. Understanding psychoneuroimmune pattern changes over time in healthy volunteers receiving mechanical load replacement and supplementation during bedrest and those who do not may have profound implications for individuals with a variety of chronic debilitating disorders; and may lead to the development of preventive, primary and secondary nursing interventions to prevent or delay the adverse effects of bedrest. This study will extend knowledge of the effects of bed rest by examining changes in patterns of bed rest related symptoms, as well as diurnal patterns of HPA and ANS activation in a sample of healthy volunteers. In this study, we will recruit subjects from a sample of healthy volunteers enrolled in the Dr. Peter R. Cavanagh study titled: A Quantitative Test of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bed Rest Analogue. The research by Dr. Cavanagh is sponsored by the National Aeronautics and Space Administration (NASA) and will be performed at the Lerner Research Institute in the Department of Biomedical Engineering and the Cleveland Clinic General Clinical Research Center (GCRC). We obtained support for our sub-study from Dr. Cavanagh study entitled: A Quantitative Tes of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bed Rest Analogue. His research is sponsored by the National Aeronautics and Space Administration (NASA) and will be performed at the Lerner Research Institute in the Department of Biomedical Engineering and the Cleveland Clinic General Clinical Research Center (GCRC). We obtained support for our sub-study from Dr. Cavanagh.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。摘要：虽然不动被认为是一个主要的压力源，有助于不良健康事件的发生率，护士研究不动的机会是有限的，在没有混杂的共病条件。将不动的应激效应与共病条件的应激效应分离的能力是本研究的主要优势。这项纵向重复测量研究的主要目的是在健康志愿者样本中检查非承重卧床随着时间的应激反应。第二个目的是检查卧床休息对睡眠模式、疲劳、抑郁、不适和疼痛的影响。卧床休息与住院患者的功能能力下降、抑郁、机构化和死亡有关。几项研究发现，由于疾病，创伤或被迫卧床休息而导致的不动是常见的，并且很大一部分进入医院的患者将经历活动能力下降和管理日常生活活动（ADLS）的能力下降，这是卧床休息的直接结果。 卧床休息并不是一个与不动和不负重相关的孤立事件;而是一个开创性的事件，它开始了一系列需要不断进行身体，情绪和社会调整的经历和条件。对卧床休息的应激反应是对这一系列级联经历和条件的反应。即使在以前健康的个体中，与知觉剥夺相结合的床上限制也会导致力量，能量和动力的损失;增加疲劳和睡眠障碍;不适以及情绪和昼夜节律的改变。了解心理神经免疫模式的变化，随着时间的推移，在健康志愿者接受机械负荷替代和补充卧床休息和那些谁不可能有深刻的影响，个人与各种慢性衰弱性疾病，并可能导致发展的预防性，初级和二级护理干预措施，以防止或延迟卧床休息的不良影响。本研究将通过检查健康志愿者样本中卧床休息相关症状模式的变化以及HPA和ANS激活的昼夜模式来扩展卧床休息影响的知识。 在本研究中，我们将从入组Dr. Peter R. Cavanagh研究标题为：使用卧床固定器对骨脱矿进行在轨运动对策的定量测试。Cavanagh博士的研究由美国国家航空航天局（NASA）赞助，将在生物医学工程系的Lerner研究所和克利夫兰临床综合临床研究中心（GCRC）进行。我们从Cavanagh博士的研究中获得了对我们子研究的支持，该研究题为：使用卧床固定器进行骨脱矿的在轨运动对策的定量测试。他的研究由美国国家航空航天局（NASA）赞助，将在生物医学工程系的勒纳研究所和克利夫兰临床综合临床研究中心（GCRC）进行。我们获得了Cavanagh博士对我们子研究的支持。