THE EFFECTIVENESS OF PERFECT TOUCH(R) IN IMPROVING CIRCULATION IN THE LOWER E

Perfect Touch(R) 在改善下腹部循环方面的功效

• 批准号: 7608211
• 负责人: AZITA TAJADDINI
• 金额: $ 0.34万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608211
• 关键词: Age; Ankle; Arteries; Blood Circulation; Blood Vessels; Blood flow; Computer Retrieval of Information on Scientific Projects Database; Data; Devices; Economic Inflation; Effectiveness; Funding; Grant; High Prevalence; Image; Individual; Institution; Investigation; Leg; Limb structure; Lower Extremity; Massage; Measures; Microcirculation; Morbidity - disease rate; Numbers; Oxygen measurement, partial pressure, arterial; Patients; Perfusion; Peripheral arterial disease; Physiological; Quality of life; Rate; Research; Research Personnel; Resources; Skin; Source; Touch sensation; United States National Institutes of Health; cardiovascular risk factor; diabetic; foot; improved; indexing; pressure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Approximately 10-20% of individuals older than 70 years have peripheral arterial disease (PAD), with a higher prevalence among diabetic patients and with increasing age. In PAD, atherosclerotic narrowing of the leg arteries limits the blood flow to the extremities, which is associated with considerable morbidity, impaired quality of life, and increased cardiovascular risk. Intermittent pneumatic compression (IPC) is promising as a conservative means of maintaining the lower extremity circulation. A number of studies have shown improvement in skin microcirculation as well as in arterial blood flow after using IPC. However, the physiological mechanism of action and efficiency of the devices are still under investigation. The Perfect Touch¿, evaluated in this study, differs from similar devices in terms of the number of chambers, inflation rate and pressure as well as the capability of massaging both foot and leg. This proposal will examine the short-term vascular benefits of this device in healthy control and those with mild to moderate PAD (0.5<ABI<0.9) (n=18 each). The vascular parameters will be the ankle/brachial index (ABI), transcutanous oxygen tension (TcPO2) and skin perfusion imaging. Local skin oxygenation of the foot will be evaluated throughout the 15-minute IPC application, while other measures are taken before and after the session. Additionally, the pressure imposed by IPC on the skin will be measured in control subjects. This study will provide preliminary data for quantifying the benefits that could result from IPC with the Perfect Touch¿ device.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 大约10-20%的70岁以上的人患有外周动脉疾病（PAD），糖尿病患者的患病率更高，并且随着年龄的增长。在PAD中，腿部动脉的动脉粥样硬化性狭窄限制了流向四肢的血流，这与相当大的发病率、生活质量受损和心血管风险增加相关。 间歇性气动加压（IPC）是一种有前途的保守手段，维持下肢循环。 许多研究表明，使用IPC后皮肤微循环和动脉血流量得到改善。 然而，该装置的生理作用机制和效率仍在研究中。 完美的触摸在本研究中评估的，在腔室数量、充气速率和压力以及按摩足部和腿部的能力方面与类似装置不同。 本提案将在健康对照组和轻度至中度PAD患者（0.5<ABI<0.9）（每组n=18）中检查该器械的短期血管获益。 血管参数为踝/臂指数（ABI）、经皮氧分压（TcPO 2）和皮肤灌注成像。 将在15分钟IPC应用过程中评估足部的局部皮肤氧合，同时在疗程前后进行其他测量。此外，将在对照受试者中测量IPC对皮肤施加的压力。 本研究将提供初步数据，用于量化使用Perfect Touch？器械进行IPC可能带来的受益。