HISTOLOGY CORE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of the Histology Core at NVCI is to make available to all investigators the expertise, facilities, techniques and technical support required for morphological, immunohistochemical and in situ analysis of cultured cells as well as animal and human tissues. The core facility supervisors are an American Board of Pathology certified pathologist and a molecular experimental scientist with high levels of training and expertise. They provide consultation to investigators on interpretation of histopathological changes in specimens and identifying optimal procedures for preparing cells and tissue of humans and experimental animals for morphologic studies. The services provided include: 1) routine paraffin-embedded histology including special histological stains, 2) immunohistochemistry on frozen and paraffin embedded tissues, and in situ analysis of mRNA, 3) tissue micro-array analysis, and 4) pathology/morphology interpretation. This core will enhance the productivity of research by providing services not available in individual laboratories and allowing investigators to concentrate on their own projects without the need to develop their own histology, immunohistochemistry and in-situ hybridization protocols. In addition, it also provides consistent, high-quality results to investigators. The INBRE award supports a half-time technician and the purchase of small equipment. In exchange for this support, all Nevada researchers are provided access to Histology core services at a discounted rate.