ENDO-CELL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该建议涉及建立异种移植人子宫内膜的功能模型。 我们从18-45岁的女性志愿者中收集子宫内膜活检组织，用于植入实验室小鼠。 目的是研究已成功用于阐明啮齿动物子宫内膜中激素相互作用机制但实际上不能用于人类受试者的药物或其他药剂。 我们已经能够成功地将人子宫内膜植入小鼠肾包膜下，并在植入后4-6周显示组织增殖。 目前，我们正在测试一种新的子宫内膜细胞周期调控途径，最近已在小鼠子宫内膜的特点。 如果成功，该项目可能为开发雌激素诱导的癌前子宫生长的靶向抑制剂提供可能的跳板。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal involves creation of a functional model of xenografted human endometrium. We collect endometrial biopsy tissue from female volunteers ages 18-45 for implantation into laboratory mice. The goal is to study drugs or other agents that have been successfully used to elucidate mechanisms of hormonal interplay in the rodent endometrium but cannot be practically given to human subjects. We have been able to successfully implant human endometrium under the mouse renal capsule and show tissue proliferation 4-6 weeks after engraftment. Currently, we are testing a novel pathway of endometrial cell cycle regulation that has been recently characterized in the mouse endometrium. If successful, this project may provide with a possible springboard for development of targeted inhibitors of estrogen-induced pre-cancerous uterine growth.