THE EFFECT OF TIME OF LEVOTHYROXINE ADMINISTRATION ON SERUM TSH

左旋甲状腺素给药时间对血清 TSH 的影响

• 批准号: 7608301
• 负责人: GIANG BACH
• 金额: $ 4.83万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608301
• 关键词: Affect; Computer Retrieval of Information on Scientific Projects Database; Fasting; Food; Funding; Gastric Emptying; Grant; Hypothyroidism; Institution; Malignant neoplasm of thyroid; Patients; Personal Satisfaction; Pharmaceutical Preparations; Research; Research Personnel; Resources; Schedule; Serum; Source; Thyroid Hormones; Thyroid carcinoma; Thyroxine; Time; United States National Institutes of Health; absorption; food consumption

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Levothyroxine is a thyroid hormone prescribed for the treatment of hypothyroidism and thyroid cancer. Although levothyroxine is well tolerated, its absorption is affected by both food and other medications. To avoid reduced or variable absorption, patients are often advised to take it on an empty stomach. However, the effects of timing of levothyroxine administration are unknown. We would like to study the effect of the timing of levothyroxine administration on serum TSH levels by prescribing its administration after fasting, at bedtime, and with food. If the timing of levothyroxine administration does not significantly affect serum TSH levels, then it is concluded that it is unnecessary for patients to adhere to a rigorous and often inconvenient medication schedule. Patients would then only have to adjust the timing of levothyroxine with respect to other medications without also adjusting it with respect to food consumption.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 左旋甲状腺素是一种甲状腺激素，用于治疗甲状腺功能减退症和甲状腺癌。 尽管左旋甲状腺素耐受性良好，但其吸收会受到食物和其他药物的影响。 为了避免吸收减少或变化，通常建议患者空腹服用。 然而，左旋甲状腺素给药时间的影响尚不清楚。 我们希望通过空腹后、睡前和与食物一起给药来研究左甲状腺素给药时间对血清 TSH 水平的影响。 如果左旋甲状腺素的给药时间不会显着影响血清 TSH 水平，则可以得出结论，患者没有必要遵守严格且通常不方便的用药时间表。 这样，患者只需根据其他药物调整左旋甲状腺素的用药时间，而无需根据食物消耗进行调整。