Perceived Cognitive function Item Bank for Children Who Undergo Cancer Treatment

描述(申请人提供)：神经认知功能的终生减退是儿童癌症幸存者最关心的问题之一，这可能会导致幸存者的心理社会问题，并蔓延到整个家庭。常规评估对存活者尤其重要，因为核因子缺陷可能在治疗数年后首次出现。目前的神经营养因子评估依赖于神经心理测试组合，这种测试组合耗时长、费用高，如果常规使用还会产生实践效果。鉴于这些障碍，需要一种测量系统，能够提供针对个人的简短和准确的评估，从而使在繁忙的临床环境中筛选需要全面神经心理测试的患者成为可能。为了满足这一需求，我们建议为7-21岁的儿童开发一个全面的认知功能题库(PCF)，以促进个性化计算机化适应性测试(CAT)和可作为筛查工具的缩写的开发。该资料库将扩充现有的成人PCF资料库，从而为在整个疾病连续和寿命范围内进行心理健康评估提供基础。我们建议为所有年龄段的儿童开发家长代理版本，并为1.3-21岁的儿童开发自我报告版本。PedsPCF银行的发展将通过成功实现以下三个目标来实现。目标1是为儿科人群生成一个认知功能项目库。我们将通过审查现有的adultPCF库中的项目和当前文献来开发这个库，该库是我们在两个联邦资助项目的范围内建立的项目库。项目将由临床医生、儿童和家长严格审查其内容有效性。将视需要增加新的项目，以反映发展差异，以确保集合的全面性。目的二是通过两个子目标的完成来检验被试(S)的心理测量学特性：a)评价被试的基本单维度；b)使用项目反应理论模型对被试(S)进行校正。目的3是对照外部临床标准，检验pedsPCF题库(S)的临床实用性。这包括：a)使用判别函数分析和接收者操作特征曲线方法来确定Cut分数；b)使用IRT来开发用户友好的简表来对患者进行全面测试；以及c)使用锚定和基于分布的方法来确定PCF中最小的重要差异。随着这个项目的完成，我们希望达到我们的最终目标，即开发一种测量系统，该系统1)可以监测患者整个发育阶段的感知认知功能，2)可以作为CAT和Short-Forms的基础，然后可以作为一种具有临床意义的筛查工具。

DESCRIPTION (provided by applicant): Lifelong decrements in neurocognitive function (NF) are among the most prominent concerns for childhood cancer survivors, which can result in psychosocial problems of survivors and extend to the entire family. Routine assessment is especially critical for survivors as NF deficits may first appear years after the treatment. Current NF assessment relies on neuropsychological test battery, which is lengthy, expensive, and produces practice effects if it is administered routinely. Given these obstacles, there is a need for a measurement system that can provide brief and precise assessments tailored to the individual, thereby making it possible to screen patients who need comprehensive neuropsychological testing in busy clinical settings. To address this need, we propose to develop a comprehensive perceived cognitive function item bank (PCF) for children 7-21 years of age, which facilitates the development of individualized computerized adaptive testing (CAT) and short-forms that can serve as the screening tool. This bank would augment an existing adult PCF bank thereby providing the basis for psychometrically sound assessment across the disease continuum and life span. We propose the development of a parent proxy version for children of all ages and a self-reported version for children ages 1.3-21. The development of the pedsPCF bank will be accomplished through the successful completion of the following three aims. Aim 1 is to generate a perceived cognitive function item pool for the pediatric population. We will develop this pool by reviewing items from the existing adultPCF bank, an item library that we have built within the scope of two federally funded projects, and current literature. Items will be rigorously reviewed by clinicians, children and parents for their content validity. New items will be added to reflect developmental differences as necessary to ensure the comprehensiveness of the pool. Aim 2 is to examine the psychometric properties of the pedsPCF item bank(s) via the completion of two sub-aims: a) evaluate the essential unidimensionality of the pedsPCF bank; and b) calibrate the item bank(s) using item response theory (IRT) models. Aim 3 is to examine the clinical usefulness of the pedsPCF item bank(s) in relation to external clinical criteria. This includes: a) using discriminant function analysis and receiver operating characteristic curve approaches to establish cut scores; b) using IRT to develop user-friendly short-forms in screening patients for comprehensive testing; and c) using both anchored and distribution based approaches to identify minimally important differences in PCF. With the completion of this project, we hope to reach our ultimate goal of developing a measurement system that 1) can monitor patient perceived cognitive function throughout developmental stages, 2) can serve as the foundation for CAT and short-forms, which can then serve as a clinically meaningful screening tool.