Etiology of Childhood Obesity: A Longitudinal Study

儿童肥胖的病因学：一项纵向研究

• 批准号: 7645811
• 负责人: Leslie A. Lytle
• 金额: $ 54.98万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7645811
• 关键词: Address; Adolescence; Age; Anthropometry; Behavior; Behavioral; Biological; Biological Factors; Birth Weight; Blood Chemical Analysis; Blood Glucose; Blood Pressure; Body Composition; Body mass index; Breast Feeding; Centers for Disease Control and Prevention (U.S.); Child; Chronic Disease; Code; Communities; Data; Data Set; Demographic Factors; Development; Diet; Distal; Eating; Economics; Ensure; Environment; Environmental Risk Factor; Epidemic; Ethnic Origin; Etiology; Family; Family history of; Fasting; Food; Funding; Future; Gender; Glean; Grant; Growth; Health; Height; Hip region structure; Home environment; Individual; Information Systems; Intake; Intervention; Life; Longitudinal Studies; Measurement; Measures; Mediating; Methodology; Methods; Modeling; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Obesity; Obesity associated disease; Overweight; Parents; Pattern; Physical activity; Physical environment; Policies; Predictive Factor; Preventive; Psychosocial Factor; Race; Recruitment Activity; Research; Research Personnel; Restaurants; Risk; Risk Factors; Sampling; Schools; Science; Socioeconomic Status; Syndrome; Testing; Time; Walking; Weight; Work; Youth; blood lipid; cardiovascular risk factor; cohort; contextual factors; demographics; experience; fast food; feeding; follow-up; health disparity; interest; modifiable risk; multidisciplinary; obesity in children; preference; prevent; psychosocial; racial and ethnic; social; socioeconomics; theories

DESCRIPTION (provided by applicant): The purpose of the Etiology of Childhood Obesity (ECHO) study is to examine the etiology of childhood obesity using a socio-ecological approach considering possible risk and protective factors at individual, family, school, and neighborhood levels. Obesity in adolescence is related to increased cardiovascular risk in adulthood. Approximately 60% of overweight youth have one CVD risk factor and another 25% have more than one risk factor. We will recruit 400 youth between the ages of 10 and 13 and one of their biological parents, conduct measurements and follow them for two years. We will target our recruitment to include youth who are at risk for, or who are overweight (at or above the 85th percentile of BMI using the CDC growth curves) and those who are in the recommended weight range and will over sample by zip code to ensure economic and racial/ethnic diversity. Individual measures on youth will include fasting blood glucose, blood lipids, anthropometry, blood pressure, and psychosocial, preference and socioeconomic status, family history related to weight including child's birth weight, early feeding (practices such as breast-feeding, family history of obesity and obesity-related chronic disease), family meal and activity patterns, and the home food and activity environments. We will measure the height, weight, waist and hip circumference of both of the youth's biological parents. For each youth in the study, we will collect data on their school environment including opportunities for physical activity, food options available in the school cafeteria and throughout the school, and school food and activity policies. Neighborhood level measures will be obtained using Geographical Information System (GIS) methodologies to assess obesogenic environmental factors such as the presence of walking and bike paths, convenience stores and fast food restaurants proximal to each youth's home and school. This research is timely and important because it will: 1) identify obesogenic factors at multiple levels of the environment guided by a social-ecological theoretical framework; 2) include a diverse sample of youth from a large, urban community; 3)'focus on modifiable risk and protective factors and use state of the science methods to measure them; 4) be directed by an experienced and multidisciplinary team of investigators; and 5) provide essential information for multi-level interventions to prevent childhood obesity.

描述（由申请人提供）：儿童肥胖病因学 (ECHO) 研究的目的是利用社会生态学方法，考虑个人、家庭、学校和社区层面可能的风险和保护因素，研究儿童肥胖的病因。青春期肥胖与成年后心血管风险增加有关。大约 60% 的超重青少年有一种 CVD 危险因素，另外 25% 的超重青少年有不止一种危险因素。我们将招募400名10至13岁的青少年及其亲生父母之一，进行测量并跟踪他们两年。我们的招募目标将包括有超重风险或超重（使用 CDC 增长曲线，BMI 等于或高于第 85 个百分位）的青少年以及处于建议体重范围内的青少年，并将按邮政编码进行抽样，以确保经济和种族/民族多样性。对青少年的个人测量包括空腹血糖、血脂、人体测量、血压、社会心理、偏好和社会经济状况、与体重相关的家族史（包括孩子的出生体重）、早期喂养（母乳喂养、肥胖家族史和肥胖相关慢性病等做法）、家庭膳食和活动模式以及家庭食物和活动环境。我们将测量青少年亲生父母的身高、体重、腰围和臀围。对于研究中的每个青少年，我们将收集有关他们学校环境的数据，包括体育活动的机会、学校食堂和整个学校提供的食物选择以及学校食物和活动政策。将使用地理信息系统（GIS）方法来获取社区层面的测量结果，以评估导致肥胖的环境因素，例如靠近每个青少年家庭和学校的步行道和自行车道、便利店和快餐店。这项研究是及时且重要的，因为它将：1）在社会生态理论框架的指导下，识别环境多个层面的肥胖因素； 2) 纳入来自大型城市社区的多样化青年样本； 3）“关注可改变的风险和保护因素，并使用最新的科学方法来衡量它们； 4）由经验丰富的多学科研究人员团队指导； 5) 为预防儿童肥胖的多层次干预措施提供重要信息。