Mitogenic and metabolic signalling via the insulin recptor isoform-A

通过胰岛素受体亚型-A 进行有丝分裂和代谢信号传导

• 批准号: nhmrc : 627210
• 负责人: A/Pr Briony Forbes
• 金额: $ 35.58万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mitogenic-metabolic-signalling-isoform-a/77644
• 关键词: Mitogenic; metabolic; signalling; via; insulin

A novel mechanism of stimulating cancer cell survival and growth has been identified which involves insulin and insulin-like growth factor-II acting via the insulin receptor isoform A. This proposal will identify the mechanisms by which these ligands stimulate growth rather than metabolism via the insulin receptor-A. This information will be used in future design of novel molecules to inhibit cancer growth without interfering with insulin's normal metabolic functions.

已经鉴定了刺激癌细胞存活和生长的新机制，其涉及胰岛素和胰岛素样生长因子-II通过胰岛素受体亚型A起作用。该建议将确定这些配体通过胰岛素受体A刺激生长而不是代谢的机制。这些信息将用于未来设计新的分子，以抑制癌症生长而不干扰胰岛素的正常代谢功能。