Functional analysis of a novel genetic mouse model for congenital growth hormone deficiency

先天性生长激素缺乏症新型基因小鼠模型的功能分析

• 批准号: nhmrc : 1011210
• 负责人: A/Pr Briony Forbes
• 金额: $ 34.62万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-analysis-novel-hormone-deficiency/109563
• 关键词: Functional; analysis; novel; genetic; mouse

Pituitary Hormone deficiency is not uncommon and is associated with poor growth, metabolism and fertility. Some cases of this disorder arise due to genetic changes that compromise the ability of the pituitary gland to make or secrete growth hormone (GH). Using cutting-edge genomics technology, we have generated a new genetic mouse model of GH deficiency. The aim of this project is to understand the function of this novel GH _regulating gene in mice and in humans.

脑垂体激素缺乏并不少见，与生长、新陈代谢和生育能力低下有关。这种疾病的一些病例是由于基因变化损害了脑下垂体制造或分泌生长激素(GH)的能力。利用尖端基因组学技术，我们建立了一种新的生长激素缺乏症小鼠遗传模型。本项目的目的是了解这种新的生长激素调节基因在小鼠和人类中的功能。