Commercializing digital wireless telemetry: the animal epilepsy monitoring unit

描述（由申请人提供）：Bio-Signal Group Corp.开发了一种微型、电池供电、多通道、便携式数字遥测系统，用于记录宽带生物电信号。DT测量生物电位具有很高的精度，因为它以24位分辨率将受试者上的信号数字化。DT与其他遥测系统最明显的区别可能是DT被设计用来记录快速和缓慢的脑电位，如动作电位（AP; 0.3-6kHz）和局部场电位（LFP）振荡，范围从0.1到500hz。无线数据传输与DT是稳健的10米，在几乎任何环境。一对2.4 GHz收发器保证1.536 Mb/s的数据速率。DT通信系统对其传输的数字数据的来源没有限制。包含1.536 Mb/s的数据可以由微处理器（MCU）以任何方式排列。DT在评估信号保真度、提供纠错和避免传输过程中的信号失真（模拟传输非常困难）方面优于模拟解决方案。与模拟系统竞争的一个关键优势是数字信号处理可以在数据从主体传输之前发生在信号源。这一创新意味着数据可以被优化、压缩和无失真地传输。在第一阶段，BSG证明了在实验室中使用DT对自由运动的大鼠进行电生理记录的可行性。我们展出了2,4和8-ch的原型装置，并精心收集了296名神经科学家的反馈，他们在最近三次神经科学学会（SfN）会议上参观了展览。这一反馈有助于确定DT在实验动物中记录自发性癫痫发作的特定需求。正在为该第二阶段项目提出创建商业交钥匙动物癫痫监测单元（aEMU）所需的具体技术发展。在第二阶段，我们将：1)小型化发射台；2)优化发射机级，实现密集、并行录音；3)电生理数据与数字录像同步；4)为使用欧洲货币联盟将产生的大型数据库创建分析软件。公共卫生相关性：了解癫痫等于了解大脑电活动与癫痫发作自发发生之间的详细关系。该项目将创建一个动物癫痫监测单元（aEMU），使研究人员能够记录自发癫痫发作的实验动物的自发大脑活动。aEMU将允许在动物的家庭环境中进行无限期的长时间录音，并且还将创建软件来分析大型信息数据库，以帮助揭示可能预测癫痫发作事件的关键生理机制，并最终导致临床治疗中的控制。

DESCRIPTION (provided by applicant): Bio-Signal Group Corp. developed a miniature, battery-operated, multi-channel, portable digital telemetry system to record wideband bioelectric signals. DT measures biopotentials with high precision because it digitizes signals on the subject at 24-bit resolution. Perhaps the most obvious feature that distinguishes the DT from other telemetric systems is the DT is designed to record both fast and slow brain potentials such as action potentials (AP; 0.3-6kHz) and local field potential (LFP) oscillations that range from 0.1 to 500 Hz. Wireless data transmission with DT is robust up to 10 m in virtually any environment. A pair of 2.4 GHz transceivers guarantees a data rate of 1.536 Mb/s. The communication system of DT has no constraints on the origin of the digital data it transmits. The data comprising the 1.536 Mb/s can be arranged in any way by the microprocessor (MCU). DT has advantages over analog solutions for assessing signal fidelity, providing error correction and avoiding signal distortion during transmission (very difficult with analog transmission). A key advantage over competing analog systems is digital signal processing can occur at the signal source before the data are transmitted from the subject. The innovation means data can be optimized, compressed, and transmitted free of distortion. In Phase I, BSG demonstrated the feasibility of using DT to make electrophysiological recordings from freely-moving rats in the laboratory. We exhibited 2,4 and 8-ch prototype devices and meticulously gathered feedback from 296 neuroscientists who visited the exhibit at the last three Society for Neuroscience (SfN) meetings. This feedback helped identify a specific need for DT to record spontaneous seizures in laboratory animals. The specific technical developments required to create a commercial turn-key animal epilepsy monitoring unit (aEMU) are being proposed for this Phase II project. In Phase II we will: 1) miniaturize the transmitter stage; 2) optimize the transmitter stage for dense and parallel recordings; 3) synchronize the electrophysiological data with digital video recording; and 4) create software for analysis of the large database that will emerge from use of the aEMU. PUBLIC HEALTH RELEVANCE: Understanding epilepsy amounts to understanding the detailed relationship between the electrical activity of the brain and the spontaneous occurrence of seizures. This project will create an animal epilepsy monitoring unit (aEMU) to allow researchers to record spontaneous brain activity in laboratory animals that have spontaneous seizures. The aEMU will permit indefinitely long recordings in the animal's home environment, and software will also be created for analyzing the large database of information to help reveal key physiological mechanisms that may predict seizure events and ultimately lead to their control in clinical treatments.