Commercializing digital wireless telemetry: the animal epilepsy monitoring unit

描述（由申请人提供）： 生物信号集团公司开发了一种微型、电池供电、多通道、便携式数字遥测系统，用于记录宽带生物电信号。DT以高精度测量生物电位，因为它以24位分辨率对受试者的信号进行数字化。也许DT与其他遥测系统最明显的区别是DT被设计为记录快速和慢速脑电位，如动作电位（AP; 0.3- 6 kHz）和局部场电位（LFP）振荡，范围从0.1到500 Hz。使用DT的无线数据传输在几乎任何环境下都能稳定传输至10 m。一对2.4 GHz收发器可保证1.536 Mb/s的数据速率。DT的通信系统对其传输的数字数据的来源没有限制。包括1.536 Mb/s的数据可以由微处理器（MCU）以任何方式排列。与模拟解决方案相比，DT在评估信号保真度、提供纠错和避免传输期间的信号失真（模拟传输非常困难）方面具有优势。与竞争性模拟系统相比，一个关键的优势是数字信号处理可以在数据从受试者传输之前在信号源处进行。这项创新意味着数据可以被优化、压缩和无失真地传输。在第一阶段，BSG证明了在实验室中使用DT对自由移动的大鼠进行电生理记录的可行性。我们展出了2，4和8通道原型设备，并仔细收集了296名神经科学家的反馈，他们在过去三次神经科学协会（SfN）会议上参观了展览。这种反馈有助于确定DT记录实验室动物自发性癫痫发作的特定需求。正在为该第二阶段项目提出建立商业交钥匙动物癫痫监测装置（aEMU）所需的具体技术发展。在第二阶段，我们将：1）简化发射器级; 2）优化发射器级，以进行密集和并行记录; 3）将电生理数据与数字视频记录同步; 4）创建软件，用于分析使用aEMU后出现的大型数据库。公共卫生相关性：了解癫痫相当于了解脑电活动与癫痫发作自发发生之间的详细关系。该项目将创建一个动物癫痫监测单元（aEMU），使研究人员能够记录自发癫痫发作的实验室动物的自发脑活动。aEMU将允许在动物的家庭环境中进行无限期的长时间记录，还将创建用于分析大型信息数据库的软件，以帮助揭示可能预测癫痫发作事件并最终导致其在临床治疗中的控制的关键生理机制。

DESCRIPTION (provided by applicant): Bio-Signal Group Corp. developed a miniature, battery-operated, multi-channel, portable digital telemetry system to record wideband bioelectric signals. DT measures biopotentials with high precision because it digitizes signals on the subject at 24-bit resolution. Perhaps the most obvious feature that distinguishes the DT from other telemetric systems is the DT is designed to record both fast and slow brain potentials such as action potentials (AP; 0.3-6kHz) and local field potential (LFP) oscillations that range from 0.1 to 500 Hz. Wireless data transmission with DT is robust up to 10 m in virtually any environment. A pair of 2.4 GHz transceivers guarantees a data rate of 1.536 Mb/s. The communication system of DT has no constraints on the origin of the digital data it transmits. The data comprising the 1.536 Mb/s can be arranged in any way by the microprocessor (MCU). DT has advantages over analog solutions for assessing signal fidelity, providing error correction and avoiding signal distortion during transmission (very difficult with analog transmission). A key advantage over competing analog systems is digital signal processing can occur at the signal source before the data are transmitted from the subject. The innovation means data can be optimized, compressed, and transmitted free of distortion. In Phase I, BSG demonstrated the feasibility of using DT to make electrophysiological recordings from freely-moving rats in the laboratory. We exhibited 2,4 and 8-ch prototype devices and meticulously gathered feedback from 296 neuroscientists who visited the exhibit at the last three Society for Neuroscience (SfN) meetings. This feedback helped identify a specific need for DT to record spontaneous seizures in laboratory animals. The specific technical developments required to create a commercial turn-key animal epilepsy monitoring unit (aEMU) are being proposed for this Phase II project. In Phase II we will: 1) miniaturize the transmitter stage; 2) optimize the transmitter stage for dense and parallel recordings; 3) synchronize the electrophysiological data with digital video recording; and 4) create software for analysis of the large database that will emerge from use of the aEMU. PUBLIC HEALTH RELEVANCE: Understanding epilepsy amounts to understanding the detailed relationship between the electrical activity of the brain and the spontaneous occurrence of seizures. This project will create an animal epilepsy monitoring unit (aEMU) to allow researchers to record spontaneous brain activity in laboratory animals that have spontaneous seizures. The aEMU will permit indefinitely long recordings in the animal's home environment, and software will also be created for analyzing the large database of information to help reveal key physiological mechanisms that may predict seizure events and ultimately lead to their control in clinical treatments.