PHYSIOLOGICAL SIGNATURE OF CACHEXIA FOR DETECTION AND THERAPUTIC MONITORING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是利用宽带漫反射光谱技术(DOS)测量和表征恶病质肌肉组织的生理特性。恶病质是一种组织在没有积极减肥的情况下消失的情况，发生在一些特定类型的癌症患者中。为了了解如何更好地诊断和治疗恶病质，我们必须首先了解组织损耗背后的机制。 这是一项首次对恶病质肌肉组织的特殊生理特征进行研究的实验。目标是(1)提高恶病质的诊断，(B)监测组织对治疗干预的反应

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to measure and characterize the physiological properties of cachexic muscle tissues using broadband diffuse optical spectroscopy (DOS). Cachexia is the condition where tissues waste away without an active attempt to loose weight, and occurs in some patients with specific types of cancer. In order to understand how to better diagnose and treat cachexia, we must first understand the mechanisms behind the wasting away of tissues. This is a pliot study, the first of its kind, to investiage specific physiological signatures of cachexic muscle tissues. the goal will be to (1) improve diagnoisis of cachexia, and (b) monitor response of tissues to theraputic intervention