CRYSTALLOGRAPHIC STUDIES OF GLUTAMINE SYNTHETASE AND TNRA FROM BACILLUS SUBTILIS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bacterial cells have an extraordinary ability to sense and respond to various changes in their environment. These cells need to detect and correctly respond to extreme variations, such as a dramatic change in essential nutrients. One very important nutrient is nitrogen, which is a key element in the production of DNA, amino acids for proteins, and many other cellular elements. Most bacteria use the amino acid glutamine as a metabolic signal for availability of nitrogen in the environment. In turn, the enzyme that produces glutamine from glutamate and ammonia, glutamine synthetase (GS), is the major target of regulation during nitrogen-limited growth.